CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense, immunosuppressive tumor microenvironment (TME) that limits therapeutic efficacy. This study investigates the role of cellular communication network factor 1 (CCN1, also known as Cyr61), an extracellular matrix‐associated p...

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Bibliographic Details
Main Authors: Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
CCN1
collagen
immunosuppressive
pancreatic cancer
tumor microenvironment
Online Access:https://doi.org/10.1002/advs.202500589
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