The potential mechanism of Saikosaponin D against luminal A breast cancer based on bioinformatical analysis, molecular docking and in vitro studies
Abstract Background Saikosaponin D (SSD) has been shown to have the strongest anti-tumor activity. This study aimed to explore the effects and potential molecular mechanism of Saikosaponin D (SSD) against estrogen receptor-positive breast cancer. Methods MCF-7 and T-47D cell lines were treated with...
Saved in:
| Main Authors: | Lichang Yang, Ru Chang, Jianzhen Pan, Shan Huang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Hereditas |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41065-025-00510-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Investigating the Therapeutic Mechanisms of Total Saikosaponins in Alzheimer’s Disease: A Metabolomic and Proteomic Approach
by: Huiling Wei, et al.
Published: (2025-01-01) -
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach
by: Genbao Zhu, et al.
Published: (2025-02-01) -
Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway
by: Yingchao Wu, et al.
Published: (2025-04-01) -
Pharmacology, medical uses, and clinical translational challenges of Saikosaponin A: A review
by: Xiao-Hong Sun, et al.
Published: (2024-11-01) -
Neuroprotective effects of saikosaponin-A in ethanol-induced glia-mediated neuroinflammation, oxidative stress via RAGE/TLR4/NFkB signaling
by: Waqar Ali, et al.
Published: (2025-08-01)