Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database
BackgroundThe hemoglobin glycation index (HGI) is defined as the difference between the observed and predicted values of glycosylated hemoglobin (HbA1c), which is closely associated with a variety of poor prognoses. However, the relationship between HGI and short-term mortality risk in patients with...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1447420/full |
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| author | Dong Chen Dong Chen Ben Hu Xing-hua Chen Xing Wei Jun Feng Ze-ping Hu |
| author_facet | Dong Chen Dong Chen Ben Hu Xing-hua Chen Xing Wei Jun Feng Ze-ping Hu |
| author_sort | Dong Chen |
| collection | DOAJ |
| description | BackgroundThe hemoglobin glycation index (HGI) is defined as the difference between the observed and predicted values of glycosylated hemoglobin (HbA1c), which is closely associated with a variety of poor prognoses. However, the relationship between HGI and short-term mortality risk in patients with a first diagnosis of acute myocardial infarction (AMI) remains unclear. This study aims to provide a better understanding of the relationship between HGI and mortality risk in patients with a first diagnosis of AMI.MethodsWe conducted a cohort study using data from 1,961 patients with a first diagnosis of AMI from the Medical Information Mart for Intensive Care IV (MIMIC-IV; version 2.2) database. Patients were divided into four groups based on HGI quartiles. A Cox proportional hazards model and a two-segmented Cox proportional hazards model were used to elucidate the non-linear relationship between HGI in patients with a first diagnosis of AMI and mortality.ResultsOf the surveyed population, 175 patients (8.92%) died within 90 days, and 210 patients (10.71%) died within 180 days. A low HGI was significantly associated with 90-day mortality [HR, 1.99; 95% CI (1.22, 3.08); P < 0.001] and 180-day mortality [HR, 1.74; 95% CI (1.18, 2.43); P < 0.001] in patients with a first diagnosis of AMI in the completely adjusted Cox proportional risk model, showing a non-linear correlation with an inflection point at 0.16 and 0.44. In the subgroup analysis, patients with prediabetes mellitus (pre-DM) and lower HGI levels had increased 90-day [HR, 8.30; 95% CI (2.91, 23.68)] and 180-day mortality risks [HR, 6.84; 95% CI (2.86, 16.34)].ConclusionThere is a significant correlation between HGI and all-cause mortality in patients diagnosed with AMI, especially those with lower HGI. HGI can serve as a potential indicator for evaluating the 90 and 180-day death risk of such patients. |
| format | Article |
| id | doaj-art-143132204b2c43a2a9165ac571fa0a90 |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-143132204b2c43a2a9165ac571fa0a902025-08-20T03:08:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-05-011210.3389/fcvm.2025.14474201447420Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV databaseDong Chen0Dong Chen1Ben Hu2Xing-hua Chen3Xing Wei4Jun Feng5Ze-ping Hu6Department of Cardiology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, ChinaDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, ChinaIntensive Care Unit, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, ChinaDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, ChinaDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, ChinaBackgroundThe hemoglobin glycation index (HGI) is defined as the difference between the observed and predicted values of glycosylated hemoglobin (HbA1c), which is closely associated with a variety of poor prognoses. However, the relationship between HGI and short-term mortality risk in patients with a first diagnosis of acute myocardial infarction (AMI) remains unclear. This study aims to provide a better understanding of the relationship between HGI and mortality risk in patients with a first diagnosis of AMI.MethodsWe conducted a cohort study using data from 1,961 patients with a first diagnosis of AMI from the Medical Information Mart for Intensive Care IV (MIMIC-IV; version 2.2) database. Patients were divided into four groups based on HGI quartiles. A Cox proportional hazards model and a two-segmented Cox proportional hazards model were used to elucidate the non-linear relationship between HGI in patients with a first diagnosis of AMI and mortality.ResultsOf the surveyed population, 175 patients (8.92%) died within 90 days, and 210 patients (10.71%) died within 180 days. A low HGI was significantly associated with 90-day mortality [HR, 1.99; 95% CI (1.22, 3.08); P < 0.001] and 180-day mortality [HR, 1.74; 95% CI (1.18, 2.43); P < 0.001] in patients with a first diagnosis of AMI in the completely adjusted Cox proportional risk model, showing a non-linear correlation with an inflection point at 0.16 and 0.44. In the subgroup analysis, patients with prediabetes mellitus (pre-DM) and lower HGI levels had increased 90-day [HR, 8.30; 95% CI (2.91, 23.68)] and 180-day mortality risks [HR, 6.84; 95% CI (2.86, 16.34)].ConclusionThere is a significant correlation between HGI and all-cause mortality in patients diagnosed with AMI, especially those with lower HGI. HGI can serve as a potential indicator for evaluating the 90 and 180-day death risk of such patients.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1447420/fullacute myocardial infarctionhemoglobin glycation indexmortalityprognosisMIMIC-IV |
| spellingShingle | Dong Chen Dong Chen Ben Hu Xing-hua Chen Xing Wei Jun Feng Ze-ping Hu Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database Frontiers in Cardiovascular Medicine acute myocardial infarction hemoglobin glycation index mortality prognosis MIMIC-IV |
| title | Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database |
| title_full | Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database |
| title_fullStr | Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database |
| title_full_unstemmed | Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database |
| title_short | Association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction: a retrospective study based on the MIMIC-IV database |
| title_sort | association between different hemoglobin glycation index and prognosis in patients with a first diagnosis of acute myocardial infarction a retrospective study based on the mimic iv database |
| topic | acute myocardial infarction hemoglobin glycation index mortality prognosis MIMIC-IV |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1447420/full |
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