Circadian influences on central nervous system barriers and the glymphatic system
The central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provided by these systems has broad implications for many physiologi...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1622236/full |
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| author | Brittany D. Elliott Claire O. Kisamore Randy J. Nelson Randy J. Nelson A. Courtney DeVries A. Courtney DeVries A. Courtney DeVries William H. Walker William H. Walker |
| author_facet | Brittany D. Elliott Claire O. Kisamore Randy J. Nelson Randy J. Nelson A. Courtney DeVries A. Courtney DeVries A. Courtney DeVries William H. Walker William H. Walker |
| author_sort | Brittany D. Elliott |
| collection | DOAJ |
| description | The central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provided by these systems has broad implications for many physiological processes and several pathological conditions are associated with their disruption. Recent studies support the notion that CNS barriers and fluids are regulated by circadian rhythms. Whereas reciprocal associations between the structural and functional integrity of neural barriers and disease states are well-established, the role of circadian rhythms in mediating these relationships remains unspecified. The goals of this review are to provide a general overview of three primary systems responsible for maintaining CNS homeostasis, namely the blood-brain barrier, blood-cerebrospinal fluid barrier, and glymphatic system, and to synthesize recent evidence highlighting the role of circadian rhythms as a critical regulator of CNS fluid and barrier function. |
| format | Article |
| id | doaj-art-142e7080801f4347b40d4e9f04563e7d |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-142e7080801f4347b40d4e9f04563e7d2025-08-20T03:47:19ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-06-011610.3389/fphys.2025.16222361622236Circadian influences on central nervous system barriers and the glymphatic systemBrittany D. Elliott0Claire O. Kisamore1Randy J. Nelson2Randy J. Nelson3A. Courtney DeVries4A. Courtney DeVries5A. Courtney DeVries6William H. Walker7William H. Walker8Department of Neuroscience, Rockefeller Neuroscience Institute, Morgantown, WV, United StatesDepartment of Neuroscience, Rockefeller Neuroscience Institute, Morgantown, WV, United StatesDepartment of Neuroscience, Rockefeller Neuroscience Institute, Morgantown, WV, United StatesWest Virginia University Cancer Institute, Morgantown, WV, United StatesDepartment of Neuroscience, Rockefeller Neuroscience Institute, Morgantown, WV, United StatesWest Virginia University Cancer Institute, Morgantown, WV, United StatesDepartment of Medical Oncology, West Virginia University, Morgantown, WV, United StatesDepartment of Neuroscience, Rockefeller Neuroscience Institute, Morgantown, WV, United StatesWest Virginia University Cancer Institute, Morgantown, WV, United StatesThe central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provided by these systems has broad implications for many physiological processes and several pathological conditions are associated with their disruption. Recent studies support the notion that CNS barriers and fluids are regulated by circadian rhythms. Whereas reciprocal associations between the structural and functional integrity of neural barriers and disease states are well-established, the role of circadian rhythms in mediating these relationships remains unspecified. The goals of this review are to provide a general overview of three primary systems responsible for maintaining CNS homeostasis, namely the blood-brain barrier, blood-cerebrospinal fluid barrier, and glymphatic system, and to synthesize recent evidence highlighting the role of circadian rhythms as a critical regulator of CNS fluid and barrier function.https://www.frontiersin.org/articles/10.3389/fphys.2025.1622236/fullcircadian rhythmsblood-brain barrierblood-cerebrospinal fluid barrierglymphatic systemCNS barriers |
| spellingShingle | Brittany D. Elliott Claire O. Kisamore Randy J. Nelson Randy J. Nelson A. Courtney DeVries A. Courtney DeVries A. Courtney DeVries William H. Walker William H. Walker Circadian influences on central nervous system barriers and the glymphatic system Frontiers in Physiology circadian rhythms blood-brain barrier blood-cerebrospinal fluid barrier glymphatic system CNS barriers |
| title | Circadian influences on central nervous system barriers and the glymphatic system |
| title_full | Circadian influences on central nervous system barriers and the glymphatic system |
| title_fullStr | Circadian influences on central nervous system barriers and the glymphatic system |
| title_full_unstemmed | Circadian influences on central nervous system barriers and the glymphatic system |
| title_short | Circadian influences on central nervous system barriers and the glymphatic system |
| title_sort | circadian influences on central nervous system barriers and the glymphatic system |
| topic | circadian rhythms blood-brain barrier blood-cerebrospinal fluid barrier glymphatic system CNS barriers |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1622236/full |
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