COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY
This multicenter, double-blind, parallel-group study compared the effects of three dihydropyridine calcium channel blockers (lercanidipine, felodipine, and nifedipine gastrointestinal therapeutic system, GITS) on blood pressure and heart rate in 250 patients with mild to moderate hypertension (diast...
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«FIRMA «SILICEA» LLC
2010-12-01
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| Series: | Российский кардиологический журнал |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1514 |
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| author | R. Romito M. I. Pansini F. Perticone G. Antonelli M. Pitzalis P. Rizzon |
| author_facet | R. Romito M. I. Pansini F. Perticone G. Antonelli M. Pitzalis P. Rizzon |
| author_sort | R. Romito |
| collection | DOAJ |
| description | This multicenter, double-blind, parallel-group study compared the effects of three dihydropyridine calcium channel blockers (lercanidipine, felodipine, and nifedipine gastrointestinal therapeutic system, GITS) on blood pressure and heart rate in 250 patients with mild to moderate hypertension (diastolic blood pressure ≥95 mm Hg and ≤109 mm Hg). Patients were randomized to 4 weeks of treatment with once-daily doses of lercanidipine 10 mg, felodipine 10 mg, or nifedipine GITS 30 mg. After 4 weeks of treatment, the dose was doubled in nonresponding patients. At 8 weeks, no significant differences in blood pressure were observed among the three groups. Increases in heart rate in all three groups induced by stressful conditions before and after treatment were not exacerbated during active treatment. The incidence of adverse drug reactions was lower in the lercanidipine and nifedipine groups than in the felodipine group (р<0,05); in particular, the incidence of edema for lercanidipine was 5,5% vs. 13% for felodipine and 6,6% for nifedipine. |
| format | Article |
| id | doaj-art-142da2c5bd8248b2bde24344bdad60af |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2010-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-142da2c5bd8248b2bde24344bdad60af2025-08-20T03:21:54Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202010-12-010645501301COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDYR. Romito0M. I. Pansini1F. PerticoneG. Antonelli2M. Pitzalis3P. Rizzon4Университет Бари, ИталияУниверситет Бари, ИталияУниверситет Бари, ИталияУниверситет Бари, ИталияУниверситет Бари, ИталияThis multicenter, double-blind, parallel-group study compared the effects of three dihydropyridine calcium channel blockers (lercanidipine, felodipine, and nifedipine gastrointestinal therapeutic system, GITS) on blood pressure and heart rate in 250 patients with mild to moderate hypertension (diastolic blood pressure ≥95 mm Hg and ≤109 mm Hg). Patients were randomized to 4 weeks of treatment with once-daily doses of lercanidipine 10 mg, felodipine 10 mg, or nifedipine GITS 30 mg. After 4 weeks of treatment, the dose was doubled in nonresponding patients. At 8 weeks, no significant differences in blood pressure were observed among the three groups. Increases in heart rate in all three groups induced by stressful conditions before and after treatment were not exacerbated during active treatment. The incidence of adverse drug reactions was lower in the lercanidipine and nifedipine groups than in the felodipine group (р<0,05); in particular, the incidence of edema for lercanidipine was 5,5% vs. 13% for felodipine and 6,6% for nifedipine.https://russjcardiol.elpub.ru/jour/article/view/1514 |
| spellingShingle | R. Romito M. I. Pansini F. Perticone G. Antonelli M. Pitzalis P. Rizzon COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY Российский кардиологический журнал |
| title | COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY |
| title_full | COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY |
| title_fullStr | COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY |
| title_full_unstemmed | COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY |
| title_short | COMPARATIVE EFFECT OF LERCANIDIPINE, FELODIPINE, AND NIFEDIPINE GITS ON BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION: THE LERCANIDIPINE IN ADULTS (LEAD) STUDY |
| title_sort | comparative effect of lercanidipine felodipine and nifedipine gits on blood pressure and heart rate in patients with mild to moderate arterial hypertension the lercanidipine in adults lead study |
| url | https://russjcardiol.elpub.ru/jour/article/view/1514 |
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