Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study
ABSTRACT Background and Aims Familial hypercholesterolemia (FH) is a substantial contributor to the development of atherosclerotic cardiovascular disease. Therefore, the primary focus of our study was to examine sex‐based disparities in clinical signs, atherosclerotic status, lipid profiles, and tre...
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Wiley
2025-03-01
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| Online Access: | https://doi.org/10.1002/hsr2.70579 |
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| author | Ngoc‐Thanh Kim Doan‐Loi Do Mai‐Ngoc Thi Nguyen Thanh‐Tung Le Hong‐An Le Thanh‐Huong Truong |
| author_facet | Ngoc‐Thanh Kim Doan‐Loi Do Mai‐Ngoc Thi Nguyen Thanh‐Tung Le Hong‐An Le Thanh‐Huong Truong |
| author_sort | Ngoc‐Thanh Kim |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Familial hypercholesterolemia (FH) is a substantial contributor to the development of atherosclerotic cardiovascular disease. Therefore, the primary focus of our study was to examine sex‐based disparities in clinical signs, atherosclerotic status, lipid profiles, and treatment intensity among patients with FH from Vietnam. Methods This retrospective cross‐sectional report analyzed the clinical profiles of 110 patients with FH from the Vietnam Familial Hypercholesterolemia (VINAFH) registry. Results Among these patients, 47 (42.7%) were females, and 48 (43.6%) had mutant FH. Women were diagnosed with FH at a significantly later age than men. However, smoking and clinical signs suggestive of FH were observed more frequently in males than in females. Male patients exhibited a higher prevalence of premature coronary artery disease than females. No significant differences in plasma total cholesterol and low‐density lipoprotein cholesterol (LDL‐C) levels were observed between sexes. In males, the areas under the curve (AUC) for plasma LDL‐C levels were 0.83, with a cut‐off value of 6.11 mmol/L (sensitivity, 79.4%; specificity, 89.7%). In females, the AUC for plasma LDL‐C levels was 0.72, with a cut‐off value of 6.9 mmol/L (sensitivity, 57.1%; specificity, 93.9%). Statins were prescribed to most patients (93.6%), with a higher proportion of men than women receiving high‐intensity statin therapy. Conclusion Our findings suggested that in Vietnam, FH is diagnosed later in women, whereas men are more likely to smoke and have atherosclerotic cardiovascular disease. Treatment intensity in female patients with FH was lower than that in male patients, despite statin prescription. |
| format | Article |
| id | doaj-art-142d6ada54644df69eeab144b39d5feb |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-142d6ada54644df69eeab144b39d5feb2025-08-20T03:42:22ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70579Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional StudyNgoc‐Thanh Kim0Doan‐Loi Do1Mai‐Ngoc Thi Nguyen2Thanh‐Tung Le3Hong‐An Le4Thanh‐Huong Truong5Department of Cardiology Hanoi Medical University Hanoi VietnamDepartment of Cardiology Hanoi Medical University Hanoi VietnamVietnam National Heart Institute, Bach Mai Hospital Hanoi VietnamVietnam National Heart Institute, Bach Mai Hospital Hanoi VietnamVietnam National Heart Institute, Bach Mai Hospital Hanoi VietnamFaculty of Medicine Phenikaa University Hanoi VietnamABSTRACT Background and Aims Familial hypercholesterolemia (FH) is a substantial contributor to the development of atherosclerotic cardiovascular disease. Therefore, the primary focus of our study was to examine sex‐based disparities in clinical signs, atherosclerotic status, lipid profiles, and treatment intensity among patients with FH from Vietnam. Methods This retrospective cross‐sectional report analyzed the clinical profiles of 110 patients with FH from the Vietnam Familial Hypercholesterolemia (VINAFH) registry. Results Among these patients, 47 (42.7%) were females, and 48 (43.6%) had mutant FH. Women were diagnosed with FH at a significantly later age than men. However, smoking and clinical signs suggestive of FH were observed more frequently in males than in females. Male patients exhibited a higher prevalence of premature coronary artery disease than females. No significant differences in plasma total cholesterol and low‐density lipoprotein cholesterol (LDL‐C) levels were observed between sexes. In males, the areas under the curve (AUC) for plasma LDL‐C levels were 0.83, with a cut‐off value of 6.11 mmol/L (sensitivity, 79.4%; specificity, 89.7%). In females, the AUC for plasma LDL‐C levels was 0.72, with a cut‐off value of 6.9 mmol/L (sensitivity, 57.1%; specificity, 93.9%). Statins were prescribed to most patients (93.6%), with a higher proportion of men than women receiving high‐intensity statin therapy. Conclusion Our findings suggested that in Vietnam, FH is diagnosed later in women, whereas men are more likely to smoke and have atherosclerotic cardiovascular disease. Treatment intensity in female patients with FH was lower than that in male patients, despite statin prescription.https://doi.org/10.1002/hsr2.70579atherosclerotic cardiovascular diseasefamilial hypercholesterolemiaLDL‐Cstatins |
| spellingShingle | Ngoc‐Thanh Kim Doan‐Loi Do Mai‐Ngoc Thi Nguyen Thanh‐Tung Le Hong‐An Le Thanh‐Huong Truong Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study Health Science Reports atherosclerotic cardiovascular disease familial hypercholesterolemia LDL‐C statins |
| title | Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study |
| title_full | Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study |
| title_fullStr | Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study |
| title_full_unstemmed | Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study |
| title_short | Sex‐Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross‐Sectional Study |
| title_sort | sex based disparities in index cases of familial hypercholesterolemia in vietnam a cross sectional study |
| topic | atherosclerotic cardiovascular disease familial hypercholesterolemia LDL‐C statins |
| url | https://doi.org/10.1002/hsr2.70579 |
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