Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing
In‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. Howe...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Advanced Intelligent Systems |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aisy.202400697 |
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| _version_ | 1850118208467501056 |
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| author | Tsz Hung Wong Jiabin Liu Yijie Cheng Yilin Xie Camryn Anway Ruihao Lu Chuwei Ye Zhaohan Yu Yuan Wang Xinyue Liu Shaoting Lin |
| author_facet | Tsz Hung Wong Jiabin Liu Yijie Cheng Yilin Xie Camryn Anway Ruihao Lu Chuwei Ye Zhaohan Yu Yuan Wang Xinyue Liu Shaoting Lin |
| author_sort | Tsz Hung Wong |
| collection | DOAJ |
| description | In‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. However, interfacing rigid, nonstretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. Herein, an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network is developed, which can rapidly and robustly adhere electrochemical biosensors with biological tissues, enabling strain‐insensitive physiological monitoring. The electrical tissue adhesive achieves a high fracture toughness of up to 3000 J m−2, a low Young's modulus of around 20 kPa, superior stretchability up to 15 times its initial length, and an overall biosensor‐tissue interfacial toughness of up to 500 J m−2. Using an electrochemical glucose sensor as one example, it is demonstrated that the electrical tissue adhesive can maintain resilient glucose sensing under various stress states and stretch levels. Additionally, the application of the electrical tissue adhesive for in‐situ monitoring of exercise and diet in subjects with various BMIs is demonstrated by measuring glucose concentration in sweat. |
| format | Article |
| id | doaj-art-142ba255203f4b6293bad3b2567f0e2f |
| institution | OA Journals |
| issn | 2640-4567 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Intelligent Systems |
| spelling | doaj-art-142ba255203f4b6293bad3b2567f0e2f2025-08-20T02:35:56ZengWileyAdvanced Intelligent Systems2640-45672025-06-0176n/an/a10.1002/aisy.202400697Electrical Tissue Adhesives for Strain‐Insensitive In‐situ BiosensingTsz Hung Wong0Jiabin Liu1Yijie Cheng2Yilin Xie3Camryn Anway4Ruihao Lu5Chuwei Ye6Zhaohan Yu7Yuan Wang8Xinyue Liu9Shaoting Lin10Department of Mechanical Engineering Michigan State University East Lansing 48824 MI USADepartment of Mechanical Engineering Michigan State University East Lansing 48824 MI USADepartment of Chemical Engineering and Materials Science Michigan State University East Lansing 48824 MI USADepartment of Animal Science Michigan State University East Lansing 48824 MI USADepartment of Mechanical Engineering Michigan State University East Lansing 48824 MI USACollege of Natural Science Michigan State University East Lansing 48824 MI USADepartment of Mechanical Engineering Michigan State University East Lansing 48824 MI USADepartment of Mechanical Engineering Michigan State University East Lansing 48824 MI USADepartment of Animal Science Michigan State University East Lansing 48824 MI USADepartment of Chemical Engineering and Materials Science Michigan State University East Lansing 48824 MI USADepartment of Mechanical Engineering Michigan State University East Lansing 48824 MI USAIn‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. However, interfacing rigid, nonstretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. Herein, an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network is developed, which can rapidly and robustly adhere electrochemical biosensors with biological tissues, enabling strain‐insensitive physiological monitoring. The electrical tissue adhesive achieves a high fracture toughness of up to 3000 J m−2, a low Young's modulus of around 20 kPa, superior stretchability up to 15 times its initial length, and an overall biosensor‐tissue interfacial toughness of up to 500 J m−2. Using an electrochemical glucose sensor as one example, it is demonstrated that the electrical tissue adhesive can maintain resilient glucose sensing under various stress states and stretch levels. Additionally, the application of the electrical tissue adhesive for in‐situ monitoring of exercise and diet in subjects with various BMIs is demonstrated by measuring glucose concentration in sweat.https://doi.org/10.1002/aisy.202400697in‐situ biosensingtissue adhesivestough hydrogels |
| spellingShingle | Tsz Hung Wong Jiabin Liu Yijie Cheng Yilin Xie Camryn Anway Ruihao Lu Chuwei Ye Zhaohan Yu Yuan Wang Xinyue Liu Shaoting Lin Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing Advanced Intelligent Systems in‐situ biosensing tissue adhesives tough hydrogels |
| title | Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing |
| title_full | Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing |
| title_fullStr | Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing |
| title_full_unstemmed | Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing |
| title_short | Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing |
| title_sort | electrical tissue adhesives for strain insensitive in situ biosensing |
| topic | in‐situ biosensing tissue adhesives tough hydrogels |
| url | https://doi.org/10.1002/aisy.202400697 |
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