Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing
In‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. Howe...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | Advanced Intelligent Systems |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aisy.202400697 |
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| Summary: | In‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. However, interfacing rigid, nonstretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. Herein, an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network is developed, which can rapidly and robustly adhere electrochemical biosensors with biological tissues, enabling strain‐insensitive physiological monitoring. The electrical tissue adhesive achieves a high fracture toughness of up to 3000 J m−2, a low Young's modulus of around 20 kPa, superior stretchability up to 15 times its initial length, and an overall biosensor‐tissue interfacial toughness of up to 500 J m−2. Using an electrochemical glucose sensor as one example, it is demonstrated that the electrical tissue adhesive can maintain resilient glucose sensing under various stress states and stretch levels. Additionally, the application of the electrical tissue adhesive for in‐situ monitoring of exercise and diet in subjects with various BMIs is demonstrated by measuring glucose concentration in sweat. |
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| ISSN: | 2640-4567 |