Research progress and prospects of virus-like particles in tumor therapy
Virus-like particles (VLPs) are hollow nanoparticles composed of one or several virus structural proteins, which have a morphological structure similar to natural viruses but do not contain any genetic material. Due to the excellent innate immunogenicity and safety of VLPs, they are often used in th...
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| Language: | English |
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Editorial Office of China Oncology
2025-06-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | https://www.china-oncology.com/fileup/1007-3639/PDF/1752457580238-1030801256.pdf |
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| author | LIU Chun, CHEN Guoxin, LI Mengtian, ZHAO Yu, MA Zhongren, ZHANG Haixia |
| author_facet | LIU Chun, CHEN Guoxin, LI Mengtian, ZHAO Yu, MA Zhongren, ZHANG Haixia |
| author_sort | LIU Chun, CHEN Guoxin, LI Mengtian, ZHAO Yu, MA Zhongren, ZHANG Haixia |
| collection | DOAJ |
| description | Virus-like particles (VLPs) are hollow nanoparticles composed of one or several virus structural proteins, which have a morphological structure similar to natural viruses but do not contain any genetic material. Due to the excellent innate immunogenicity and safety of VLPs, they are often used in the development of tumor vaccines. In addition, compared with traditional drug delivery vectors, VLPs have better biocompatibility and strong targeting ability, making them highly valued in the delivery of anti-tumor drugs. In recent years, the efficient delivery of gene editing tools using VLPs has provided new possibilities for tumor treatment. VLPs can inhibit tumor growth and spread through various mechanisms, such as activating immune responses to suppress tumor growth, stimulating the body's immune system, promoting the expression of tumor associated antigens, and enhancing the body's ability to recognize and clear tumor cells. These studies not only broaden the application scope of VLPs in the field of anti-tumor therapy, but also provide a broader prospect for future research and application. This article reviewed the research progress of VLPs derived from different viruses in preventive or therapeutic vaccines and drug delivery carriers, and explored new development strategies. |
| format | Article |
| id | doaj-art-141ecded376f48969e9496f0e7e7a73c |
| institution | Kabale University |
| issn | 1007-3639 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj-art-141ecded376f48969e9496f0e7e7a73c2025-08-20T03:34:26ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392025-06-0135658559110.19401/j.cnki.1007-3639.2025.06.008Research progress and prospects of virus-like particles in tumor therapyLIU Chun, CHEN Guoxin, LI Mengtian, ZHAO Yu, MA Zhongren, ZHANG Haixia01. Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Lanzhou 730030, Gansu Province, China;2. Biomedical Research Center, Key Laboratory of Bioengineering and Biotechnology of the State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou 730030, Gansu Province, China;3. Biomedical Research Center, Animal Cell Technology Innovation Center of Gansu Province, Northwest Minzu University, Lanzhou 730030, Gansu Province, ChinaVirus-like particles (VLPs) are hollow nanoparticles composed of one or several virus structural proteins, which have a morphological structure similar to natural viruses but do not contain any genetic material. Due to the excellent innate immunogenicity and safety of VLPs, they are often used in the development of tumor vaccines. In addition, compared with traditional drug delivery vectors, VLPs have better biocompatibility and strong targeting ability, making them highly valued in the delivery of anti-tumor drugs. In recent years, the efficient delivery of gene editing tools using VLPs has provided new possibilities for tumor treatment. VLPs can inhibit tumor growth and spread through various mechanisms, such as activating immune responses to suppress tumor growth, stimulating the body's immune system, promoting the expression of tumor associated antigens, and enhancing the body's ability to recognize and clear tumor cells. These studies not only broaden the application scope of VLPs in the field of anti-tumor therapy, but also provide a broader prospect for future research and application. This article reviewed the research progress of VLPs derived from different viruses in preventive or therapeutic vaccines and drug delivery carriers, and explored new development strategies.https://www.china-oncology.com/fileup/1007-3639/PDF/1752457580238-1030801256.pdf|virus-like particles|drug delivery vehicles|antitumor drug|tumor vaccine |
| spellingShingle | LIU Chun, CHEN Guoxin, LI Mengtian, ZHAO Yu, MA Zhongren, ZHANG Haixia Research progress and prospects of virus-like particles in tumor therapy Zhongguo aizheng zazhi |virus-like particles|drug delivery vehicles|antitumor drug|tumor vaccine |
| title | Research progress and prospects of virus-like particles in tumor therapy |
| title_full | Research progress and prospects of virus-like particles in tumor therapy |
| title_fullStr | Research progress and prospects of virus-like particles in tumor therapy |
| title_full_unstemmed | Research progress and prospects of virus-like particles in tumor therapy |
| title_short | Research progress and prospects of virus-like particles in tumor therapy |
| title_sort | research progress and prospects of virus like particles in tumor therapy |
| topic | |virus-like particles|drug delivery vehicles|antitumor drug|tumor vaccine |
| url | https://www.china-oncology.com/fileup/1007-3639/PDF/1752457580238-1030801256.pdf |
| work_keys_str_mv | AT liuchunchenguoxinlimengtianzhaoyumazhongrenzhanghaixia researchprogressandprospectsofviruslikeparticlesintumortherapy |