High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China.
Currently, five types of duck hepatitis viruses have been documented, and they are all associated with liver disorders. However, the prevalence of their coinfections involving these viruses remains largely uncertain. Herein, we screened the prevalence of the five types of hepatitis viruses from A to...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0324682 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849688137184313344 |
|---|---|
| author | Xiaoming Lin Lizhen Gong Yajia Gou Yi Liu Sai Mao Shun Chen Mafeng Liu Dekang Zhu Mingshu Wang Renyong Jia Shaqiu Zhang Ying Wu Juan Huang Bin Tian Qiao Yang Xinxin Zhao Anchun Cheng Xumin Ou |
| author_facet | Xiaoming Lin Lizhen Gong Yajia Gou Yi Liu Sai Mao Shun Chen Mafeng Liu Dekang Zhu Mingshu Wang Renyong Jia Shaqiu Zhang Ying Wu Juan Huang Bin Tian Qiao Yang Xinxin Zhao Anchun Cheng Xumin Ou |
| author_sort | Xiaoming Lin |
| collection | DOAJ |
| description | Currently, five types of duck hepatitis viruses have been documented, and they are all associated with liver disorders. However, the prevalence of their coinfections involving these viruses remains largely uncertain. Herein, we screened the prevalence of the five types of hepatitis viruses from A to E in 143 samples of diseased duck livers during 2019-2021 in Southwest China. We found the highest infection ratio (86.01%, 123/143) of duck hepatitis B virus (DHBV) among all five types of hepatitis viruses. Importantly, a large portion of DHBV-associated coinfections were identified, with 52.85% (65/123) co-infected with Duck Hepatitis A virus (DHAV), 39.84% (49/123) with tentative Duck Hepatitis D virus (DHDV), and 34.96% (43/123) with Duck Hepatitis E virus (DHEV), respectively. Interestingly, a positive correlation between the DHBV-positive rate and the infection rates of the other co-infected hepatitis viruses was revealed, suggesting the importance of DHBV in duck hepatitis virus co-infection events. To understand the situation of bacterial secondary infection, the prevalence of bacterial infection was simultaneously screened using standard 16S rRNA PCR, and hepatitis virus-associated bacterial infections were observed. Collectively, these findings revealed a high prevalence of DHBV-related coinfections and its association with the coinfection of the other duck hepatitis viruses and bacteria. In the future, it is important to study the impact of DHBV co-infection events on disease severity, thereby evaluating the necessity of vaccine development for DHBV. |
| format | Article |
| id | doaj-art-141c6bcad9d6465c8b8199f33e8f63b4 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-141c6bcad9d6465c8b8199f33e8f63b42025-08-20T03:22:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032468210.1371/journal.pone.0324682High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China.Xiaoming LinLizhen GongYajia GouYi LiuSai MaoShun ChenMafeng LiuDekang ZhuMingshu WangRenyong JiaShaqiu ZhangYing WuJuan HuangBin TianQiao YangXinxin ZhaoAnchun ChengXumin OuCurrently, five types of duck hepatitis viruses have been documented, and they are all associated with liver disorders. However, the prevalence of their coinfections involving these viruses remains largely uncertain. Herein, we screened the prevalence of the five types of hepatitis viruses from A to E in 143 samples of diseased duck livers during 2019-2021 in Southwest China. We found the highest infection ratio (86.01%, 123/143) of duck hepatitis B virus (DHBV) among all five types of hepatitis viruses. Importantly, a large portion of DHBV-associated coinfections were identified, with 52.85% (65/123) co-infected with Duck Hepatitis A virus (DHAV), 39.84% (49/123) with tentative Duck Hepatitis D virus (DHDV), and 34.96% (43/123) with Duck Hepatitis E virus (DHEV), respectively. Interestingly, a positive correlation between the DHBV-positive rate and the infection rates of the other co-infected hepatitis viruses was revealed, suggesting the importance of DHBV in duck hepatitis virus co-infection events. To understand the situation of bacterial secondary infection, the prevalence of bacterial infection was simultaneously screened using standard 16S rRNA PCR, and hepatitis virus-associated bacterial infections were observed. Collectively, these findings revealed a high prevalence of DHBV-related coinfections and its association with the coinfection of the other duck hepatitis viruses and bacteria. In the future, it is important to study the impact of DHBV co-infection events on disease severity, thereby evaluating the necessity of vaccine development for DHBV.https://doi.org/10.1371/journal.pone.0324682 |
| spellingShingle | Xiaoming Lin Lizhen Gong Yajia Gou Yi Liu Sai Mao Shun Chen Mafeng Liu Dekang Zhu Mingshu Wang Renyong Jia Shaqiu Zhang Ying Wu Juan Huang Bin Tian Qiao Yang Xinxin Zhao Anchun Cheng Xumin Ou High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. PLoS ONE |
| title | High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. |
| title_full | High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. |
| title_fullStr | High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. |
| title_full_unstemmed | High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. |
| title_short | High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. |
| title_sort | high prevalence of duck hepatitis b virus associated coinfection in southwest china |
| url | https://doi.org/10.1371/journal.pone.0324682 |
| work_keys_str_mv | AT xiaominglin highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT lizhengong highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT yajiagou highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT yiliu highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT saimao highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT shunchen highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT mafengliu highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT dekangzhu highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT mingshuwang highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT renyongjia highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT shaqiuzhang highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT yingwu highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT juanhuang highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT bintian highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT qiaoyang highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT xinxinzhao highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT anchuncheng highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina AT xuminou highprevalenceofduckhepatitisbvirusassociatedcoinfectioninsouthwestchina |