Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)
Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.Participants Bet...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/9/e086543.full |
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| author | PA Crisinel P Paioni N Müller A Anagnostopoulos M Hoffmann Huldrych Günthard J Böni J Schüpbach M Baumann D Nadal Christoph Rudin M Egger C-A Siegrist N Wagner J Németh A Duppenthaler J Notter L Kaiser J-J CHESEAUX P Schmid A Rauch M Huber C Rudin B Ledergerber A Calmy M Cavassini M Rickenbach H Furrer M Battegay L Elzi Andri Rauch B Hirschel E Bernasconi HC Bucher J Fehr J Fellay CA Fux D Haerry B Hasse HH Hirsch I Hösli O Keiser T Klimkait H Kovari B Martinez de Tejada G Pantaleo R Speck P Tarr A Trkola S Yerly P Francioli Andrea Duppenthaler Karoline Aebi-Popp Noemie Wagner Paolo Paioni Murezi Capaul Anja Brunner Anna Traytel Pierre-Alex Crisinel Begona Martinez De Tejada Lisa Kottanattu Marcel Stöckle Irene Hösli Alexandra Scherrer Katharina Kusejko Christian R Kahlert I Abela K Aebi-Popp DL Braun A Ciuffi K Darling G Dollenmaier K Francini HF Günthard A Hachfeld D Jackson-Perry CR Kahlert E Kapfhammer M Kohns L Kottanattu RD Kouyos K Kusejko N Labhardt C Marzolini KJ Metzner D Nicca M Perreau Polli Ch L Salazar-Vizcaya M Stöckle M Thanh Lecompte G Wandeler M Weisser C Kind |
| author_facet | PA Crisinel P Paioni N Müller A Anagnostopoulos M Hoffmann Huldrych Günthard J Böni J Schüpbach M Baumann D Nadal Christoph Rudin M Egger C-A Siegrist N Wagner J Németh A Duppenthaler J Notter L Kaiser J-J CHESEAUX P Schmid A Rauch M Huber C Rudin B Ledergerber A Calmy M Cavassini M Rickenbach H Furrer M Battegay L Elzi Andri Rauch B Hirschel E Bernasconi HC Bucher J Fehr J Fellay CA Fux D Haerry B Hasse HH Hirsch I Hösli O Keiser T Klimkait H Kovari B Martinez de Tejada G Pantaleo R Speck P Tarr A Trkola S Yerly P Francioli Andrea Duppenthaler Karoline Aebi-Popp Noemie Wagner Paolo Paioni Murezi Capaul Anja Brunner Anna Traytel Pierre-Alex Crisinel Begona Martinez De Tejada Lisa Kottanattu Marcel Stöckle Irene Hösli Alexandra Scherrer Katharina Kusejko Christian R Kahlert I Abela K Aebi-Popp DL Braun A Ciuffi K Darling G Dollenmaier K Francini HF Günthard A Hachfeld D Jackson-Perry CR Kahlert E Kapfhammer M Kohns L Kottanattu RD Kouyos K Kusejko N Labhardt C Marzolini KJ Metzner D Nicca M Perreau Polli Ch L Salazar-Vizcaya M Stöckle M Thanh Lecompte G Wandeler M Weisser C Kind |
| collection | DOAJ |
| description | Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.Participants Between January 1986 and December 2022, a total of 1446 mother–child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.Findings to date During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.Future plans Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH. |
| format | Article |
| id | doaj-art-141a8a7fc8fb4df38900406381bf05e0 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-141a8a7fc8fb4df38900406381bf05e02025-08-20T01:54:31ZengBMJ Publishing GroupBMJ Open2044-60552024-09-0114910.1136/bmjopen-2024-086543Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) PA CrisinelP PaioniN MüllerA AnagnostopoulosM HoffmannHuldrych Günthard0J BöniJ SchüpbachM BaumannD NadalChristoph Rudin1M EggerC-A SiegristN WagnerJ NémethA DuppenthalerJ NotterL KaiserJ-J CHESEAUXP SchmidA RauchM HuberC RudinB LedergerberA CalmyM CavassiniM RickenbachH FurrerM BattegayL ElziAndri Rauch2B HirschelE BernasconiHC BucherJ FehrJ FellayCA FuxD HaerryB HasseHH HirschI HösliO KeiserT KlimkaitH KovariB Martinez de TejadaG PantaleoR SpeckP TarrA TrkolaS YerlyP FrancioliAndrea Duppenthaler3Karoline Aebi-Popp4Noemie Wagner5Paolo Paioni6Murezi Capaul7Anja Brunner8Anna Traytel9Pierre-Alex Crisinel10Begona Martinez De Tejada11Lisa Kottanattu12Marcel Stöckle13Irene Hösli14Alexandra Scherrer15Katharina Kusejko16Christian R Kahlert17I AbelaK Aebi-PoppDL BraunA CiuffiK DarlingG DollenmaierK FranciniHF GünthardA HachfeldD Jackson-PerryCR KahlertE KapfhammerM KohnsL KottanattuRD KouyosK KusejkoN LabhardtC MarzoliniKJ MetznerD NiccaM PerreauPolli ChL Salazar-VizcayaM StöckleM Thanh LecompteG WandelerM WeisserC KindDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandUniversity Children`s Hospital Basel, Basel, SwitzerlandDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, SwitzerlandPediatric Infectious Diseases Unit, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneve, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Children’s Hospital Zurich, Zurich, SwitzerlandDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandFrauenklinik, Bürgerspital Solothurn, Solothurn, SwitzerlandDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandUnit of Pediatric Infectious Diseases and Vaccinology, Department of Woman Mother and Child, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandObstetrics Division. Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, University of Geneva, Geneva, SwitzerlandInstitute of Pediatrics of Southern Switzerland, EOC, Bellinzona, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, SwitzerlandDepartment of Obstetrics, University Hospital Basel, Basel, SwitzerlandDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandCantonal Hospital St. Gallen, Department of Infectious Diseases, Infection Prevention and Travel Medicine, St Gallen, SwitzerlandPurpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.Participants Between January 1986 and December 2022, a total of 1446 mother–child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.Findings to date During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.Future plans Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.https://bmjopen.bmj.com/content/14/9/e086543.full |
| spellingShingle | PA Crisinel P Paioni N Müller A Anagnostopoulos M Hoffmann Huldrych Günthard J Böni J Schüpbach M Baumann D Nadal Christoph Rudin M Egger C-A Siegrist N Wagner J Németh A Duppenthaler J Notter L Kaiser J-J CHESEAUX P Schmid A Rauch M Huber C Rudin B Ledergerber A Calmy M Cavassini M Rickenbach H Furrer M Battegay L Elzi Andri Rauch B Hirschel E Bernasconi HC Bucher J Fehr J Fellay CA Fux D Haerry B Hasse HH Hirsch I Hösli O Keiser T Klimkait H Kovari B Martinez de Tejada G Pantaleo R Speck P Tarr A Trkola S Yerly P Francioli Andrea Duppenthaler Karoline Aebi-Popp Noemie Wagner Paolo Paioni Murezi Capaul Anja Brunner Anna Traytel Pierre-Alex Crisinel Begona Martinez De Tejada Lisa Kottanattu Marcel Stöckle Irene Hösli Alexandra Scherrer Katharina Kusejko Christian R Kahlert I Abela K Aebi-Popp DL Braun A Ciuffi K Darling G Dollenmaier K Francini HF Günthard A Hachfeld D Jackson-Perry CR Kahlert E Kapfhammer M Kohns L Kottanattu RD Kouyos K Kusejko N Labhardt C Marzolini KJ Metzner D Nicca M Perreau Polli Ch L Salazar-Vizcaya M Stöckle M Thanh Lecompte G Wandeler M Weisser C Kind Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) BMJ Open |
| title | Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) |
| title_full | Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) |
| title_fullStr | Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) |
| title_full_unstemmed | Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) |
| title_short | Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV) |
| title_sort | cohort profile the swiss mother and child hiv cohort study mochiv |
| url | https://bmjopen.bmj.com/content/14/9/e086543.full |
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