Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma

IntroductionChimeric antigen receptor T (CAR-T) cell therapy presents a promising treatment option for various cancers, including solid tumors. Carcinoembryonic antigen (CEA) is an attractive target due to its high expression in many tumors, particularly gastrointestinal cancers, while limited expre...

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Bibliographic Details
Main Authors: Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T cells
carcinoembryonic antigen
single-chain fragment variable
affinity
cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182409/full
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