Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale

Background Given the increasing diversity among neurological patients, standardised protocols are essential for evaluating the severity and complexity of the variety of conditions. The aim of the present work was to standardise the assessment of the severity and complexity of neurological impairment...

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Main Authors: Alessandro Padovani, Andrea Pilotto, Andrea Morotti, Ilenia Libri, Stefano Gipponi, Nicola Zoppi, Giulia Ceccardi, Lynne Turner-Stokes, Chiara Agosti, Valentina Mazzoleni, Debora Pezzini, Irene Mattioli, Tiziana Comunale, Cinzia Zatti, Enis Guso, Marcello Catania, Davide Arici, Marco Bolchini, Luca Colombo, Marco Di Cesare, Michele Di Pasquale, Lucia Ferullo, Bianca Gumina, Beatrice Labella, Alessandro Lupini, Emanuele Olivieri, Maria Teresa Piscitelli, Leandro Purin, Mattia Quaccini, Elisabetta Rolla, Chiara Silvestri, Maddalena Toffali, Silvio Zampini, Andrea Zancanaro, Daniele Zanola
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:BMJ Neurology Open
Online Access:https://neurologyopen.bmj.com/content/7/1/e001107.full
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author Alessandro Padovani
Andrea Pilotto
Andrea Morotti
Ilenia Libri
Stefano Gipponi
Nicola Zoppi
Giulia Ceccardi
Lynne Turner-Stokes
Chiara Agosti
Valentina Mazzoleni
Debora Pezzini
Irene Mattioli
Tiziana Comunale
Cinzia Zatti
Enis Guso
Marcello Catania
Davide Arici
Marco Bolchini
Luca Colombo
Marco Di Cesare
Michele Di Pasquale
Lucia Ferullo
Bianca Gumina
Beatrice Labella
Alessandro Lupini
Emanuele Olivieri
Maria Teresa Piscitelli
Leandro Purin
Mattia Quaccini
Elisabetta Rolla
Chiara Silvestri
Maddalena Toffali
Silvio Zampini
Andrea Zancanaro
Daniele Zanola
author_facet Alessandro Padovani
Andrea Pilotto
Andrea Morotti
Ilenia Libri
Stefano Gipponi
Nicola Zoppi
Giulia Ceccardi
Lynne Turner-Stokes
Chiara Agosti
Valentina Mazzoleni
Debora Pezzini
Irene Mattioli
Tiziana Comunale
Cinzia Zatti
Enis Guso
Marcello Catania
Davide Arici
Marco Bolchini
Luca Colombo
Marco Di Cesare
Michele Di Pasquale
Lucia Ferullo
Bianca Gumina
Beatrice Labella
Alessandro Lupini
Emanuele Olivieri
Maria Teresa Piscitelli
Leandro Purin
Mattia Quaccini
Elisabetta Rolla
Chiara Silvestri
Maddalena Toffali
Silvio Zampini
Andrea Zancanaro
Daniele Zanola
collection DOAJ
description Background Given the increasing diversity among neurological patients, standardised protocols are essential for evaluating the severity and complexity of the variety of conditions. The aim of the present work was to standardise the assessment of the severity and complexity of neurological impairment in an acute setting by using a modified version of the Neurological Impairment Scale (mNIS).Methods Consecutively hospitalised neurological inpatients underwent a multidimensional standardised assessment of multimorbidity, frailty, functional dependency and neurological impairment using mNIS and other validated scales. Inter-rater reliability of the mNIS total and subscores was evaluated. Construct validity was assessed separately in patients with cerebrovascular disease, performing correlations between corresponding subscores of mNIS, original NIS and National Institutes of Health Stroke Scale. mNIS Complexity Index (mNIS-CI) for neurological severity was used to classify patients into subtle, mild, moderate and severe impairment.Results 1081 neurological patients admitted to a neurological ward from the emergency setting were enrolled. The inter-rater reliability was remarkable for mNIS total and subscores (intraclass correlation coefficient 0.90, 95% CI 0.82 to 0.95). The mNIS showed strong construct validity for total and subscores compared with other clinical scales (r 0.47–0.97, p<0.001) and 52.7% of patients scored at least one in one of the four newly listed items. The stratification of patients according to mNIS-CI exhibited high construct validity, distinguishing the extent of impairment and involved domains.Conclusions The mNIS is valuable for measuring neurological severity and complexity in acute inpatients and holds significant potential for application in different settings.
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spelling doaj-art-1401b38feb9f4dc0bf3bc11ed233702a2025-08-20T03:27:58ZengBMJ Publishing GroupBMJ Neurology Open2632-61402025-06-017110.1136/bmjno-2025-001107Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale Alessandro Padovani0Andrea Pilotto1Andrea Morotti2Ilenia Libri3Stefano Gipponi4Nicola Zoppi5Giulia Ceccardi6Lynne Turner-Stokes7Chiara Agosti8Valentina Mazzoleni9Debora Pezzini10Irene Mattioli11Tiziana Comunale12Cinzia Zatti13Enis Guso14Marcello Catania15Davide AriciMarco BolchiniLuca ColomboMarco Di CesareMichele Di PasqualeLucia FerulloBianca GuminaBeatrice LabellaAlessandro LupiniEmanuele OlivieriMaria Teresa PiscitelliLeandro PurinMattia QuacciniElisabetta RollaChiara SilvestriMaddalena ToffaliSilvio ZampiniAndrea ZancanaroDaniele ZanolaNeurology Unit and Laboratory of digital Neurology and biosensors, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyNeurology Unit and Laboratory of digital Neurology and biosensors, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy1 Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy1 Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyDepartment of Neurology, San Jacopo Hospital, Pistoia, Italy1 Neurology Unit, IRCCS Ospedale San Raffaele, Milano, Italy6 Regional Rehabilitation Unit, Northwick Park Hospital, London, UKDepartment of Frailty and Continuity of Care, ASST Spedali Civili di Brescia, Brescia, ItalyDipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, ItaliaDipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, ItaliaDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyBackground Given the increasing diversity among neurological patients, standardised protocols are essential for evaluating the severity and complexity of the variety of conditions. The aim of the present work was to standardise the assessment of the severity and complexity of neurological impairment in an acute setting by using a modified version of the Neurological Impairment Scale (mNIS).Methods Consecutively hospitalised neurological inpatients underwent a multidimensional standardised assessment of multimorbidity, frailty, functional dependency and neurological impairment using mNIS and other validated scales. Inter-rater reliability of the mNIS total and subscores was evaluated. Construct validity was assessed separately in patients with cerebrovascular disease, performing correlations between corresponding subscores of mNIS, original NIS and National Institutes of Health Stroke Scale. mNIS Complexity Index (mNIS-CI) for neurological severity was used to classify patients into subtle, mild, moderate and severe impairment.Results 1081 neurological patients admitted to a neurological ward from the emergency setting were enrolled. The inter-rater reliability was remarkable for mNIS total and subscores (intraclass correlation coefficient 0.90, 95% CI 0.82 to 0.95). The mNIS showed strong construct validity for total and subscores compared with other clinical scales (r 0.47–0.97, p<0.001) and 52.7% of patients scored at least one in one of the four newly listed items. The stratification of patients according to mNIS-CI exhibited high construct validity, distinguishing the extent of impairment and involved domains.Conclusions The mNIS is valuable for measuring neurological severity and complexity in acute inpatients and holds significant potential for application in different settings.https://neurologyopen.bmj.com/content/7/1/e001107.full
spellingShingle Alessandro Padovani
Andrea Pilotto
Andrea Morotti
Ilenia Libri
Stefano Gipponi
Nicola Zoppi
Giulia Ceccardi
Lynne Turner-Stokes
Chiara Agosti
Valentina Mazzoleni
Debora Pezzini
Irene Mattioli
Tiziana Comunale
Cinzia Zatti
Enis Guso
Marcello Catania
Davide Arici
Marco Bolchini
Luca Colombo
Marco Di Cesare
Michele Di Pasquale
Lucia Ferullo
Bianca Gumina
Beatrice Labella
Alessandro Lupini
Emanuele Olivieri
Maria Teresa Piscitelli
Leandro Purin
Mattia Quaccini
Elisabetta Rolla
Chiara Silvestri
Maddalena Toffali
Silvio Zampini
Andrea Zancanaro
Daniele Zanola
Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
BMJ Neurology Open
title Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
title_full Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
title_fullStr Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
title_full_unstemmed Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
title_short Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale
title_sort measuring neurological severity and complexity in acute setting the modified neurological impairment scale
url https://neurologyopen.bmj.com/content/7/1/e001107.full
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