Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study
Background. Several studies have shown that lymphocyte subsets can mediate the occurrence of osteoporosis (OP); however, the predictive ability of lymphocyte subsets in senile OP has not been elucidated. Purpose. To investigate the ability of lymphocyte subsets to predict senile osteoporosis (OP). M...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/3337622 |
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| author | Cong Peng Zongwei Guo Yue Zhao Rui Li Liang Wang Wenping Gong |
| author_facet | Cong Peng Zongwei Guo Yue Zhao Rui Li Liang Wang Wenping Gong |
| author_sort | Cong Peng |
| collection | DOAJ |
| description | Background. Several studies have shown that lymphocyte subsets can mediate the occurrence of osteoporosis (OP); however, the predictive ability of lymphocyte subsets in senile OP has not been elucidated. Purpose. To investigate the ability of lymphocyte subsets to predict senile osteoporosis (OP). Methods and Materials. This study included 44 patients with senile OP and 44 without OP. Dual-energy X-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD). Flow cytometry was used to analyze the absolute counts of the lymphocyte subsets and cytokine levels. Finally, the correlation between BMD and lymphocyte subset counts in the two groups was analyzed. Results. There were no significant differences in age, sex, or weight between the OP and non-OP groups. The absolute counts of total T lymphocytes and CD8+ T lymphocytes in the OP group were significantly lower than those in the non-OP group. The levels of IFN-γ or TNF-α in the OP group were significantly higher or lower, respectively, than those in the non-OP group. PCA showed that age, BMI, total T lymphocytes, CD4+ T lymphocytes, CD8+ T lymphocytes, and B lymphocytes were the principal components of senile OP. The linear regression equation showed that BMD of the right femoral neck significantly decreased with a decline in CD8+ T lymphocyte counts. Conclusion. BMD decreased with a decrease in CD8+ T lymphocytes. The mechanism by which lower lymphocyte subsets lead to lower BMD may be related to abnormal bone metabolism caused by immune aging. Therefore, we considered that CD8+ T lymphocytes could be used to predict the incidence of senile OP. |
| format | Article |
| id | doaj-art-13ff8f448d2f48eb9571ab6ba45d904a |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-13ff8f448d2f48eb9571ab6ba45d904a2025-08-20T03:54:33ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/3337622Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective StudyCong Peng0Zongwei Guo1Yue Zhao2Rui Li3Liang Wang4Wenping Gong5Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentInstitute of Respiratory and Critical Medicine/Beijing Key Laboratory of OTIRAcademy of Integrated Chinese and Western MedicineHebei North UniversityDepartment of GeriatricsTuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentBackground. Several studies have shown that lymphocyte subsets can mediate the occurrence of osteoporosis (OP); however, the predictive ability of lymphocyte subsets in senile OP has not been elucidated. Purpose. To investigate the ability of lymphocyte subsets to predict senile osteoporosis (OP). Methods and Materials. This study included 44 patients with senile OP and 44 without OP. Dual-energy X-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD). Flow cytometry was used to analyze the absolute counts of the lymphocyte subsets and cytokine levels. Finally, the correlation between BMD and lymphocyte subset counts in the two groups was analyzed. Results. There were no significant differences in age, sex, or weight between the OP and non-OP groups. The absolute counts of total T lymphocytes and CD8+ T lymphocytes in the OP group were significantly lower than those in the non-OP group. The levels of IFN-γ or TNF-α in the OP group were significantly higher or lower, respectively, than those in the non-OP group. PCA showed that age, BMI, total T lymphocytes, CD4+ T lymphocytes, CD8+ T lymphocytes, and B lymphocytes were the principal components of senile OP. The linear regression equation showed that BMD of the right femoral neck significantly decreased with a decline in CD8+ T lymphocyte counts. Conclusion. BMD decreased with a decrease in CD8+ T lymphocytes. The mechanism by which lower lymphocyte subsets lead to lower BMD may be related to abnormal bone metabolism caused by immune aging. Therefore, we considered that CD8+ T lymphocytes could be used to predict the incidence of senile OP.http://dx.doi.org/10.1155/2022/3337622 |
| spellingShingle | Cong Peng Zongwei Guo Yue Zhao Rui Li Liang Wang Wenping Gong Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study Journal of Immunology Research |
| title | Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study |
| title_full | Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study |
| title_fullStr | Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study |
| title_full_unstemmed | Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study |
| title_short | Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study |
| title_sort | effect of lymphocyte subsets on bone density in senile osteoporosis a retrospective study |
| url | http://dx.doi.org/10.1155/2022/3337622 |
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