Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India
Background: There is supporting evidence on the use of nortriptyline in smoking; however, its effectiveness in smokeless tobacco cessation has not been studied. Objectives: The objectives of this study were to evaluate the effectiveness of oral bupropion and nortriptyline in reducing smokeless tobac...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Indian Journal of Public Health |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijph.ijph_400_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850082993966678016 |
|---|---|
| author | Aparajita Guin Hoineiting Rebecca Haokip Sanjib Bandyopadhyay Saibal Das Indranil Saha Aniruddha Basu Stuti Bhargava |
| author_facet | Aparajita Guin Hoineiting Rebecca Haokip Sanjib Bandyopadhyay Saibal Das Indranil Saha Aniruddha Basu Stuti Bhargava |
| author_sort | Aparajita Guin |
| collection | DOAJ |
| description | Background:
There is supporting evidence on the use of nortriptyline in smoking; however, its effectiveness in smokeless tobacco cessation has not been studied.
Objectives:
The objectives of this study were to evaluate the effectiveness of oral bupropion and nortriptyline in reducing smokeless tobacco use.
Materials and Methods:
In this retrospective study, 85 smokeless tobacco users who required pharmacotherapy (either bupropion or nortriptyline) in addition to behavioral counseling and standard nicotine replacement therapy were included in the study. The amount of tobacco use and Fagerström test for nicotine dependence (FTND)-smokeless tobacco score were compared at the end of 3 months of treatment.
Results:
Among 84 patients (92.9% males); 39 (46.4%) received bupropion and 45 (53.6%) received nortriptyline. Of them, 97.4% of patients who received bupropion and 84.4% who received nortriptyline reported reduced usage of smokeless tobacco after treatment (P = 0.06). There was a significant reduction in the average use of smokeless tobacco after treatment as compared to baseline usage among patients who received bupropion (median [Q1–Q3], 360 [150–600] to 8 [0–60]) and nortriptyline (median [Q1–Q3], 90 [0–465] to 0 [0–60]). Similarly, there were significant reductions in the median FTND-smokeless tobacco scores after treatment as compared to baseline scorings among patients who received bupropion (median, 6 [4–7] to 0 [0–0.5]) and nortriptyline (median, 6 [4–8] to 0 [0–0.25]). Both bupropion and nortriptyline were found to be safe.
Conclusion:
Adjunct bupropion and nortriptyline were similarly efficacious in reducing smokeless tobacco use. This has clinical significance because nortriptyline is much cheaper than bupropion. |
| format | Article |
| id | doaj-art-13fd9162e9124a17a8b70e2004c8bea7 |
| institution | DOAJ |
| issn | 0019-557X 2229-7693 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Public Health |
| spelling | doaj-art-13fd9162e9124a17a8b70e2004c8bea72025-08-20T02:44:23ZengWolters Kluwer Medknow PublicationsIndian Journal of Public Health0019-557X2229-76932025-04-0169218519010.4103/ijph.ijph_400_24Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern IndiaAparajita GuinHoineiting Rebecca HaokipSanjib BandyopadhyaySaibal DasIndranil SahaAniruddha BasuStuti BhargavaBackground: There is supporting evidence on the use of nortriptyline in smoking; however, its effectiveness in smokeless tobacco cessation has not been studied. Objectives: The objectives of this study were to evaluate the effectiveness of oral bupropion and nortriptyline in reducing smokeless tobacco use. Materials and Methods: In this retrospective study, 85 smokeless tobacco users who required pharmacotherapy (either bupropion or nortriptyline) in addition to behavioral counseling and standard nicotine replacement therapy were included in the study. The amount of tobacco use and Fagerström test for nicotine dependence (FTND)-smokeless tobacco score were compared at the end of 3 months of treatment. Results: Among 84 patients (92.9% males); 39 (46.4%) received bupropion and 45 (53.6%) received nortriptyline. Of them, 97.4% of patients who received bupropion and 84.4% who received nortriptyline reported reduced usage of smokeless tobacco after treatment (P = 0.06). There was a significant reduction in the average use of smokeless tobacco after treatment as compared to baseline usage among patients who received bupropion (median [Q1–Q3], 360 [150–600] to 8 [0–60]) and nortriptyline (median [Q1–Q3], 90 [0–465] to 0 [0–60]). Similarly, there were significant reductions in the median FTND-smokeless tobacco scores after treatment as compared to baseline scorings among patients who received bupropion (median, 6 [4–7] to 0 [0–0.5]) and nortriptyline (median, 6 [4–8] to 0 [0–0.25]). Both bupropion and nortriptyline were found to be safe. Conclusion: Adjunct bupropion and nortriptyline were similarly efficacious in reducing smokeless tobacco use. This has clinical significance because nortriptyline is much cheaper than bupropion.https://journals.lww.com/10.4103/ijph.ijph_400_24bupropionfagerström test for nicotine dependencenortriptylinesmokeless tobacco |
| spellingShingle | Aparajita Guin Hoineiting Rebecca Haokip Sanjib Bandyopadhyay Saibal Das Indranil Saha Aniruddha Basu Stuti Bhargava Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India Indian Journal of Public Health bupropion fagerström test for nicotine dependence nortriptyline smokeless tobacco |
| title | Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India |
| title_full | Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India |
| title_fullStr | Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India |
| title_full_unstemmed | Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India |
| title_short | Effectiveness of Oral Bupropion and Nortriptyline as an Adjunct Treatment for Reducing the Use of Smokeless Tobacco: A Retrospective Study from a Tobacco Cessation Clinic in a Tertiary Care Hospital in Eastern India |
| title_sort | effectiveness of oral bupropion and nortriptyline as an adjunct treatment for reducing the use of smokeless tobacco a retrospective study from a tobacco cessation clinic in a tertiary care hospital in eastern india |
| topic | bupropion fagerström test for nicotine dependence nortriptyline smokeless tobacco |
| url | https://journals.lww.com/10.4103/ijph.ijph_400_24 |
| work_keys_str_mv | AT aparajitaguin effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT hoineitingrebeccahaokip effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT sanjibbandyopadhyay effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT saibaldas effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT indranilsaha effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT aniruddhabasu effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia AT stutibhargava effectivenessoforalbupropionandnortriptylineasanadjuncttreatmentforreducingtheuseofsmokelesstobaccoaretrospectivestudyfromatobaccocessationclinicinatertiarycarehospitalineasternindia |