On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma
Chordomas are rare malignant tumors of notochordal origin and are rare locally aggressive ones with a metastatic potential. The skin rarely is seen as metastatic site. We describe a case of an adult woman with cutaneous metastasis of a primary sacral chordoma excised ten years before, which appeared...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2017/5281239 |
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| author | Alessandro D’Amuri Matteo Brunelli Federica Floccari Francesco De Caro Giuliana Crisman Francesca Sanguedolce Marcello Filotico |
| author_facet | Alessandro D’Amuri Matteo Brunelli Federica Floccari Francesco De Caro Giuliana Crisman Francesca Sanguedolce Marcello Filotico |
| author_sort | Alessandro D’Amuri |
| collection | DOAJ |
| description | Chordomas are rare malignant tumors of notochordal origin and are rare locally aggressive ones with a metastatic potential. The skin rarely is seen as metastatic site. We describe a case of an adult woman with cutaneous metastasis of a primary sacral chordoma excised ten years before, which appeared as a painless cutaneous mass located in the dorsal region. Once removed, the surgical specimen was formalin fixed and in paraffin embedded. Sections were stained with haematoxylin-eosin, and histochemical and immunohistochemical investigations were performed. Histologically, the neoplasia was characterized by cords or single tumor cells with an abundant myxoid stroma, conspicuous pale vacuolated cytoplasm (the classic “physaliphorous cells”), and mild nuclear atypia. Mitotic activity was scanty. At immunohistochemistry, the tumor cells were diffusely positive for S-100 protein, pan-keratins, EMA, and vimentin. A diagnosis of cutaneous metastasis of chordoma was performed. This case illustrates a diagnostic challenge because of the unusual presentation of an already rare tumor. |
| format | Article |
| id | doaj-art-13fb7ebb270b4b3ca20cf2b10c44edda |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-13fb7ebb270b4b3ca20cf2b10c44edda2025-08-20T02:04:51ZengWileyCase Reports in Pathology2090-67812090-679X2017-01-01201710.1155/2017/52812395281239On a Rare Cutaneous Metastasis from a Sacrococcygeal ChordomaAlessandro D’Amuri0Matteo Brunelli1Federica Floccari2Francesco De Caro3Giuliana Crisman4Francesca Sanguedolce5Marcello Filotico6Anatomic Pathology Unit, Card. G. Panico Hospital, Tricase, ItalyDepartment of Diagnostics and Public Health, Anatomic Pathology, University and Hospital Trust, Verona, ItalyClinic Pathology Unit, Sacro Cuore di Gesù Hospital, Gallipoli, ItalyOrthopaedics and Traumatology Unit, Sacro Cuore di Gesù Hospital, Gallipoli, ItalyPathology Unit, Desenzano del Garda General Hospital, Brescia, ItalyDepartment of Pathology, University and Hospital Trust, Riuniti Hospital, Foggia, ItalyAnatomic Pathology Unit, Card. G. Panico Hospital, Tricase, ItalyChordomas are rare malignant tumors of notochordal origin and are rare locally aggressive ones with a metastatic potential. The skin rarely is seen as metastatic site. We describe a case of an adult woman with cutaneous metastasis of a primary sacral chordoma excised ten years before, which appeared as a painless cutaneous mass located in the dorsal region. Once removed, the surgical specimen was formalin fixed and in paraffin embedded. Sections were stained with haematoxylin-eosin, and histochemical and immunohistochemical investigations were performed. Histologically, the neoplasia was characterized by cords or single tumor cells with an abundant myxoid stroma, conspicuous pale vacuolated cytoplasm (the classic “physaliphorous cells”), and mild nuclear atypia. Mitotic activity was scanty. At immunohistochemistry, the tumor cells were diffusely positive for S-100 protein, pan-keratins, EMA, and vimentin. A diagnosis of cutaneous metastasis of chordoma was performed. This case illustrates a diagnostic challenge because of the unusual presentation of an already rare tumor.http://dx.doi.org/10.1155/2017/5281239 |
| spellingShingle | Alessandro D’Amuri Matteo Brunelli Federica Floccari Francesco De Caro Giuliana Crisman Francesca Sanguedolce Marcello Filotico On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma Case Reports in Pathology |
| title | On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma |
| title_full | On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma |
| title_fullStr | On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma |
| title_full_unstemmed | On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma |
| title_short | On a Rare Cutaneous Metastasis from a Sacrococcygeal Chordoma |
| title_sort | on a rare cutaneous metastasis from a sacrococcygeal chordoma |
| url | http://dx.doi.org/10.1155/2017/5281239 |
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