Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with the tendency for tumor invasion and metastasis, creates significant challenges for current therapeutic approaches. Additionally, the pharmaceutical agents curr...
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MDPI AG
2025-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/8/1827 |
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| author | Jiacheng Yao Feng Zhu Yikun Feng Chen Gu Tianyu Wang Xinyu Li Hao Yang Xiamin Hu Pierre-Antoine Bonnet Xiangguo Meng |
| author_facet | Jiacheng Yao Feng Zhu Yikun Feng Chen Gu Tianyu Wang Xinyu Li Hao Yang Xiamin Hu Pierre-Antoine Bonnet Xiangguo Meng |
| author_sort | Jiacheng Yao |
| collection | DOAJ |
| description | Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with the tendency for tumor invasion and metastasis, creates significant challenges for current therapeutic approaches. Additionally, the pharmaceutical agents currently used to treat NSCLC often come with severe side effects and can lead to drug resistance. As a result, there is an urgent need to develop new therapeutic agents with fewer side effects that can effectively overcome resistance mechanisms. Flavonoids, a prominent class of natural compounds, have shown promise in preventing and treating various cancers. By structurally optimizing flavonoids, it is possible to enhance their anticancer activity and improve their pharmacokinetic properties. This article reviews the different mechanisms of action and structure–activity relationships (SARs) of flavonoid derivatives in treating NSCLC, aiming to provide a scientific foundation for developing new therapeutic agents. |
| format | Article |
| id | doaj-art-13fac04eea5e4f65af7b89305639dc24 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-13fac04eea5e4f65af7b89305639dc242025-08-20T02:28:32ZengMDPI AGMolecules1420-30492025-04-01308182710.3390/molecules30081827Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung CancerJiacheng Yao0Feng Zhu1Yikun Feng2Chen Gu3Tianyu Wang4Xinyu Li5Hao Yang6Xiamin Hu7Pierre-Antoine Bonnet8Xiangguo Meng9Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaYangzijiang Pharmaceutical Group Shanghai Haini Pharmaceutical Co., Ltd., Shanghai 201318, ChinaGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaFaculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaFaculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaFaculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaIBMM, Faculty of Pharmacy, Montpellier University, CNRS, ENSCM, 34093 Montpellier, FranceFaculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaNon-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with the tendency for tumor invasion and metastasis, creates significant challenges for current therapeutic approaches. Additionally, the pharmaceutical agents currently used to treat NSCLC often come with severe side effects and can lead to drug resistance. As a result, there is an urgent need to develop new therapeutic agents with fewer side effects that can effectively overcome resistance mechanisms. Flavonoids, a prominent class of natural compounds, have shown promise in preventing and treating various cancers. By structurally optimizing flavonoids, it is possible to enhance their anticancer activity and improve their pharmacokinetic properties. This article reviews the different mechanisms of action and structure–activity relationships (SARs) of flavonoid derivatives in treating NSCLC, aiming to provide a scientific foundation for developing new therapeutic agents.https://www.mdpi.com/1420-3049/30/8/1827flavonoidsanti-tumor mechanismstructure–activity relationshipsnatural productsderivatelung cancer |
| spellingShingle | Jiacheng Yao Feng Zhu Yikun Feng Chen Gu Tianyu Wang Xinyu Li Hao Yang Xiamin Hu Pierre-Antoine Bonnet Xiangguo Meng Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer Molecules flavonoids anti-tumor mechanism structure–activity relationships natural products derivate lung cancer |
| title | Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer |
| title_full | Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer |
| title_fullStr | Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer |
| title_full_unstemmed | Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer |
| title_short | Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer |
| title_sort | research progress on the structure activity relationship and mechanism of flavonoid derivatives in the treatment of lung cancer |
| topic | flavonoids anti-tumor mechanism structure–activity relationships natural products derivate lung cancer |
| url | https://www.mdpi.com/1420-3049/30/8/1827 |
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