An orally bioavailable BRD4 inhibitor disrupts expansion of a pathogenic epithelial-mesenchymal niche in bleomycin-induced fibrosis

An orally bioavailable BRD4 inhibitor disrupts expansion of a pathogenic epithelial-mesenchymal niche in bleomycin-induced fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and fatal disease with few effective therapies available. Fibrosis is driven, in part, by cell-state transitions of epithelial progenitors within the airways that repopulate the injured alveoli. This alveolar atypi...

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Main Authors: Melissa Skibba, Zonghui Ma, Carole L. Wilson, Zhiqing Liu, Haiying Chen, Bing Tian, Thomas J. Harr, Lynn M Schnapp, Nathan Sandbo, Jia Zhou, Allan R. Brasier
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Online Access:https://doi.org/10.1186/s12931-025-03306-6
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