Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort
Abstract Purpose Diagnosis with UICC stage IV colorectal cancer often indicates palliative treatment to alleviate symptoms. Data on pain in these patients are still scarce but can help improve symptom management. This study therefore aimed to describe patient-reported pain and quality of life. Metho...
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| Language: | English |
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Springer
2025-03-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-025-06186-x |
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| author | Sophie Klara Schellack Clara Breidenbach Christoph Kowalski Ulrich Wedding Birgitt van Oorschot Thomas Seufferlein Stefan Benz Martin Schnell Jörg Köninger Christina Klein Johann Ockenga Björn Freitag Uwe A. Wittel Roger Wahba Mia Kim Saleem Elhabash Pompiliu Piso Dirk Weyhe Jörg Bunse Maren Riechmann Marco von Strauss Sebastian Petzoldt Philipp-Alexander Neumann Vanessa Kolb Nora Tabea Sibert |
| author_facet | Sophie Klara Schellack Clara Breidenbach Christoph Kowalski Ulrich Wedding Birgitt van Oorschot Thomas Seufferlein Stefan Benz Martin Schnell Jörg Köninger Christina Klein Johann Ockenga Björn Freitag Uwe A. Wittel Roger Wahba Mia Kim Saleem Elhabash Pompiliu Piso Dirk Weyhe Jörg Bunse Maren Riechmann Marco von Strauss Sebastian Petzoldt Philipp-Alexander Neumann Vanessa Kolb Nora Tabea Sibert |
| author_sort | Sophie Klara Schellack |
| collection | DOAJ |
| description | Abstract Purpose Diagnosis with UICC stage IV colorectal cancer often indicates palliative treatment to alleviate symptoms. Data on pain in these patients are still scarce but can help improve symptom management. This study therefore aimed to describe patient-reported pain and quality of life. Methods 147 palliatively treated stage IV colorectal cancer patients diagnosed between 2018 and 2023 completed the EORTC QLQ-C30 and QLQ-CR29 before and 12 months after treatment initiation within the EDIUM study. Descriptive results for pain and quality of life were examined and compared to reference values. A logistic regression analysis investigated the relationship between quality of life and pain and 1-year survival. Results The mean (SD) for the “overall pain” score was 26 (32) (T0) and 35 (32) (T1) for rectal cancer patients and 34 (33) (T0) and 35 (32) (T1) for colon cancer patients. This is higher than the reference value (24 (30)) and indicates high average pain levels. The “overall quality of life” score showed means below the reference value (61 (23)), indicating poorer quality of life (colon: 51 (25) (T0), 56 (22) (T1); rectum: 52 (24) (T0), 51 (22) (T1)). Higher pain levels persisted at both time points, with no patients reporting absence of pain. The logistic regression results suggest a small relationship between pain and quality of life and 1-year survival. Discussion This study reveals high levels of pain among palliatively treated colorectal cancer patients, impacting their quality of life. Effective pain management and close monitoring are necessary to improve the quality of life for these patients. Trail number DRKS00008724. |
| format | Article |
| id | doaj-art-13f04064b4c849efa732eddfbcf4f1f8 |
| institution | OA Journals |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
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| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-13f04064b4c849efa732eddfbcf4f1f82025-08-20T01:51:59ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-03-0115141910.1007/s00432-025-06186-xPain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohortSophie Klara Schellack0Clara Breidenbach1Christoph Kowalski2Ulrich Wedding3Birgitt van Oorschot4Thomas Seufferlein5Stefan Benz6Martin Schnell7Jörg Köninger8Christina Klein9Johann Ockenga10Björn Freitag11Uwe A. Wittel12Roger Wahba13Mia Kim14Saleem Elhabash15Pompiliu Piso16Dirk Weyhe17Jörg Bunse18Maren Riechmann19Marco von Strauss20Sebastian Petzoldt21Philipp-Alexander Neumann22Vanessa Kolb23Nora Tabea Sibert24German Cancer SocietyGerman Cancer SocietyGerman Cancer SocietyUniversity Medicine JenaUniversity of WürzburgUniversity Medicine UlmKlinikum Sindelfingen-BöblingenHegau-Bodensee-Klinikum SingenKlinikum StuttgartHelios Park-Klinikum LeipzigBremen Klinikum Bremen-MitteSt. Josef-HospitalKliniken Nordoberpfalz– Klinikum WeidenHelios Klinikum Berlin-BuchMünchen Klinik NeuperlachJohannes Wesling Klinikum MindenBarmherzige Brüder RegensburgPius Hospital University Medicine OldenburgSana Klinikum LichtenbergSana Klinikum Hof, HochfrankenSt. Claraspital BaselDRK Kliniken Berlin-Treptow– KöpenickKlinikum rechts der Isar, TUM University Hospital, TU MunichOnkoZert GmbHGerman Cancer SocietyAbstract Purpose Diagnosis with UICC stage IV colorectal cancer often indicates palliative treatment to alleviate symptoms. Data on pain in these patients are still scarce but can help improve symptom management. This study therefore aimed to describe patient-reported pain and quality of life. Methods 147 palliatively treated stage IV colorectal cancer patients diagnosed between 2018 and 2023 completed the EORTC QLQ-C30 and QLQ-CR29 before and 12 months after treatment initiation within the EDIUM study. Descriptive results for pain and quality of life were examined and compared to reference values. A logistic regression analysis investigated the relationship between quality of life and pain and 1-year survival. Results The mean (SD) for the “overall pain” score was 26 (32) (T0) and 35 (32) (T1) for rectal cancer patients and 34 (33) (T0) and 35 (32) (T1) for colon cancer patients. This is higher than the reference value (24 (30)) and indicates high average pain levels. The “overall quality of life” score showed means below the reference value (61 (23)), indicating poorer quality of life (colon: 51 (25) (T0), 56 (22) (T1); rectum: 52 (24) (T0), 51 (22) (T1)). Higher pain levels persisted at both time points, with no patients reporting absence of pain. The logistic regression results suggest a small relationship between pain and quality of life and 1-year survival. Discussion This study reveals high levels of pain among palliatively treated colorectal cancer patients, impacting their quality of life. Effective pain management and close monitoring are necessary to improve the quality of life for these patients. Trail number DRKS00008724.https://doi.org/10.1007/s00432-025-06186-xPalliative careColorectal neoplasmsPatient reported outcomesPainQuality of life |
| spellingShingle | Sophie Klara Schellack Clara Breidenbach Christoph Kowalski Ulrich Wedding Birgitt van Oorschot Thomas Seufferlein Stefan Benz Martin Schnell Jörg Köninger Christina Klein Johann Ockenga Björn Freitag Uwe A. Wittel Roger Wahba Mia Kim Saleem Elhabash Pompiliu Piso Dirk Weyhe Jörg Bunse Maren Riechmann Marco von Strauss Sebastian Petzoldt Philipp-Alexander Neumann Vanessa Kolb Nora Tabea Sibert Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort Journal of Cancer Research and Clinical Oncology Palliative care Colorectal neoplasms Patient reported outcomes Pain Quality of life |
| title | Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort |
| title_full | Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort |
| title_fullStr | Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort |
| title_full_unstemmed | Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort |
| title_short | Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort |
| title_sort | pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis results from the edium cohort |
| topic | Palliative care Colorectal neoplasms Patient reported outcomes Pain Quality of life |
| url | https://doi.org/10.1007/s00432-025-06186-x |
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