Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing
We examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL). Patients undergoing nuclear myocardial perfusion stress imagi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/425923 |
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| author | Mikko Haapio Andrew A. House Massimo de Cal Dinna N. Cruz Paolo Lentini Davide Giavarina Antonio Fortunato Luigi Menghetti Matteo Salgarello Andrea Lupi Giuliano Soffiati Alessandro Fontanelli Pierluigi Zanco Claudio Ronco |
| author_facet | Mikko Haapio Andrew A. House Massimo de Cal Dinna N. Cruz Paolo Lentini Davide Giavarina Antonio Fortunato Luigi Menghetti Matteo Salgarello Andrea Lupi Giuliano Soffiati Alessandro Fontanelli Pierluigi Zanco Claudio Ronco |
| author_sort | Mikko Haapio |
| collection | DOAJ |
| description | We examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL). Patients undergoing nuclear myocardial perfusion stress imaging were divided into 2 groups. Biomarkers were analyzed pre- and poststress testing. Compared to the patients in the low ischemia group (n=16), the patients in the high ischemia group (n=18) demonstrated a significantly greater rise in cardiac biomarkers plasma BNP, NT-proBNP and cTnI. Subjects were also categorized based on pre- or poststress test detectable plasma NGAL. With stress, the group with no detectable NGAL had a segmental defect score 4.2 compared to 8.2 (P=.06) in the detectable NGAL group, and 0.9 vs. 3.8 (P=.03) at rest. BNP rose with stress to a greater degree in patients with detectable NGAL (10.2 vs. 3.5 pg/mL, P=.03). LVEF at rest and with stress was significantly lower in the detectable NGAL group; 55.8 versus 65.0 (P=.03) and 55.1 vs. 63.8 (P=.04), respectively. Myocardial perfusion defects associate with biomarkers of cardiac stress, and detectable plasma NGAL with significantly lower LVEF, suggesting a specific heart-kidney link. |
| format | Article |
| id | doaj-art-13ef4fdd529443c4a17140c48fa6ef33 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-13ef4fdd529443c4a17140c48fa6ef332025-02-03T01:12:37ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/425923425923Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress TestingMikko Haapio0Andrew A. House1Massimo de Cal2Dinna N. Cruz3Paolo Lentini4Davide Giavarina5Antonio Fortunato6Luigi Menghetti7Matteo Salgarello8Andrea Lupi9Giuliano Soffiati10Alessandro Fontanelli11Pierluigi Zanco12Claudio Ronco13Division of Nephrology, Meilahti Hospital, HUCH, P.O. Box 340, 00029 Helsinki, FinlandDepartment of Nephrology, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nephrology, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nephrology, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nephrology, St. Bortolo Hospital, 36100 Vicenza, ItalyClinical Chemistry and Haematology Laboratory, St. Bortolo Hospital, 36100 Vicenza, ItalyClinical Chemistry and Haematology Laboratory, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Cardiology, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nuclear Medicine, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nuclear Medicine, St. Bortolo Hospital, 36100 Vicenza, ItalyClinical Chemistry and Haematology Laboratory, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Cardiology, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nuclear Medicine, St. Bortolo Hospital, 36100 Vicenza, ItalyDepartment of Nephrology, St. Bortolo Hospital, 36100 Vicenza, ItalyWe examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL). Patients undergoing nuclear myocardial perfusion stress imaging were divided into 2 groups. Biomarkers were analyzed pre- and poststress testing. Compared to the patients in the low ischemia group (n=16), the patients in the high ischemia group (n=18) demonstrated a significantly greater rise in cardiac biomarkers plasma BNP, NT-proBNP and cTnI. Subjects were also categorized based on pre- or poststress test detectable plasma NGAL. With stress, the group with no detectable NGAL had a segmental defect score 4.2 compared to 8.2 (P=.06) in the detectable NGAL group, and 0.9 vs. 3.8 (P=.03) at rest. BNP rose with stress to a greater degree in patients with detectable NGAL (10.2 vs. 3.5 pg/mL, P=.03). LVEF at rest and with stress was significantly lower in the detectable NGAL group; 55.8 versus 65.0 (P=.03) and 55.1 vs. 63.8 (P=.04), respectively. Myocardial perfusion defects associate with biomarkers of cardiac stress, and detectable plasma NGAL with significantly lower LVEF, suggesting a specific heart-kidney link.http://dx.doi.org/10.4061/2011/425923 |
| spellingShingle | Mikko Haapio Andrew A. House Massimo de Cal Dinna N. Cruz Paolo Lentini Davide Giavarina Antonio Fortunato Luigi Menghetti Matteo Salgarello Andrea Lupi Giuliano Soffiati Alessandro Fontanelli Pierluigi Zanco Claudio Ronco Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing International Journal of Nephrology |
| title | Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing |
| title_full | Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing |
| title_fullStr | Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing |
| title_full_unstemmed | Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing |
| title_short | Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing |
| title_sort | heart kidney biomarkers in patients undergoing cardiac stress testing |
| url | http://dx.doi.org/10.4061/2011/425923 |
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