Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis
Background: An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work. Methods: Fo...
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Elsevier
2023-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422023000550 |
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| author | Lu Ding Cui Li Peiming Zhang Chen Chen Jie Zhan Jinchun Zeng Liming Lu |
| author_facet | Lu Ding Cui Li Peiming Zhang Chen Chen Jie Zhan Jinchun Zeng Liming Lu |
| author_sort | Lu Ding |
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| description | Background: An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work. Methods: Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms. Results: Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], P = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], P = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], P = 0.005) with high heterogeneity. Conclusions: Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials. Study registration: The protocol of this review has been registered at PROSPERO (CRD42022335505). |
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| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
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| series | Integrative Medicine Research |
| spelling | doaj-art-13e449fc1a1c4d83abc8d2c33336edf32025-08-20T02:04:51ZengElsevierIntegrative Medicine Research2213-42202023-09-0112310097610.1016/j.imr.2023.100976Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysisLu Ding0Cui Li1Peiming Zhang2Chen Chen3Jie Zhan4Jinchun Zeng5Liming Lu6Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaClinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Acupuncture and Moxibustion, Foshan Hospital of Traditional Chinese Medicine, Foshan, ChinaClinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaPostdoctoral Research Station, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaDepartment of Rehabilitation, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China; Corresponding authors at: Department of Rehabilitation, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Airport Road, Baiyun District, Guangzhou 510405, China (J. Zeng); Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 232 Wai Huan Dong Road, Guangzhou, China (L. Lu).Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China; Corresponding authors at: Department of Rehabilitation, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 16 Airport Road, Baiyun District, Guangzhou 510405, China (J. Zeng); Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 232 Wai Huan Dong Road, Guangzhou, China (L. Lu).Background: An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work. Methods: Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms. Results: Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], P = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], P = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], P = 0.005) with high heterogeneity. Conclusions: Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials. Study registration: The protocol of this review has been registered at PROSPERO (CRD42022335505).http://www.sciencedirect.com/science/article/pii/S2213422023000550AcupunctureProtracted opioid abstinence syndromeSystematic reviewMeta-analysis |
| spellingShingle | Lu Ding Cui Li Peiming Zhang Chen Chen Jie Zhan Jinchun Zeng Liming Lu Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis Integrative Medicine Research Acupuncture Protracted opioid abstinence syndrome Systematic review Meta-analysis |
| title | Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis |
| title_full | Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis |
| title_fullStr | Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis |
| title_full_unstemmed | Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis |
| title_short | Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis |
| title_sort | acupuncture related therapies for protracted opioid abstinence syndrome a systematic review and meta analysis |
| topic | Acupuncture Protracted opioid abstinence syndrome Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2213422023000550 |
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