A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma

A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma

Abstract Background Nonseminomatous testicular germ cell tumors (NSE) present significant diagnostic challenges, especially for the early detection of serum tumor marker (STM) negative cases. Current diagnostic tools are limited, highlighting the need for innovative approaches. This study investigat...

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Main Authors: Jure Krasic, Dinko Soic, Lucija Skara Abramovic, Ivona Kolosnjaj, Miroslav Tomic, Alen Vrtaric, Sasa Kralik Oguic, Nina Gelo, Ana Katusic Bojanac, Davor Jezek, Dinko Mitrecic, Monika Ulamec, Tomislav Kulis, Olga Gornik, Nino Sincic
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Cell-free DNA
N-glycosylation
Epigenetics
Biomarkers
Testicular germ cell tumors
Semen quality
Online Access:https://doi.org/10.1186/s12935-025-03887-8
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