Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins
To address the challenge of vertical bone augmentation in orofacial surgery and implant dentistry, this study focused on additively manufactured 3D architectural glass–ceramic scaffolds (3DP). The 3DP, which mimics the Haversian canal and trabecular porous structure, was innovatively designed and fa...
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Elsevier
2025-05-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525004095 |
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| author | Wenjie Wang Lingling Zheng Wei Liu Chunjuan Wang Dan Chen Liya Ai Antonio Apicella Chao Wang Yubo Fan |
| author_facet | Wenjie Wang Lingling Zheng Wei Liu Chunjuan Wang Dan Chen Liya Ai Antonio Apicella Chao Wang Yubo Fan |
| author_sort | Wenjie Wang |
| collection | DOAJ |
| description | To address the challenge of vertical bone augmentation in orofacial surgery and implant dentistry, this study focused on additively manufactured 3D architectural glass–ceramic scaffolds (3DP). The 3DP, which mimics the Haversian canal and trabecular porous structure, was innovatively designed and fabricated using Digital Laser Processing (DLP) additive manufacturing. The morphology, microstructure, elemental composition and mechanical characteristics of 3DP were compared with those of bovine Xenogeneic Bone Block (XBB), human Allogeneic Bone Block (ABH), and rabbit Autogenous Bone Block (ABR). Furthermore, the vertical osteogenic capacity using a rabbit calvarium model were compared among them. Micro-CT and histology analyses revealed that the osteogenic height, volume, and area of 3DP and XBB were superior to those of ABH and ABR, and 3DP demonstrated a more rapid vertical osteogenesis compared to XBB. The excellent vertical osteogenic performance of 3DP should be attributed to the ideal pore size of its microporous structure, the spatial maintaining force of its overall architecture, and its microcrystalline chemical composition after sintering. Moreover, the vertical channels in the porous network seemed to promote the rapid vertical growth of bone tissue at the early stage. |
| format | Article |
| id | doaj-art-13db864e5ee74281becd9363825bfeff |
| institution | DOAJ |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-13db864e5ee74281becd9363825bfeff2025-08-20T03:22:04ZengElsevierMaterials & Design0264-12752025-05-0125311398910.1016/j.matdes.2025.113989Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different originsWenjie Wang0Lingling Zheng1Wei Liu2Chunjuan Wang3Dan Chen4Liya Ai5Antonio Apicella6Chao Wang7Yubo Fan8Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, China; Department of Stomatology, Aerospace Center Hospital, Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, ChinaDepartment of Stomatology, The Fourth Affiliated Hospital of Inner Mongolia Medical University, Baotou, ChinaStomatological Hospital of Chongqing Medical University, No.426, Songshi North Road, Chongqing 401147, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, ChinaPolytechnique School of Engineering and Base Science, University of Campania, Abbazia di San Lorenzo, Aversa, (CE) 81031, ItalyKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, China; Stomatological Hospital of Chongqing Medical University, No.426, Songshi North Road, Chongqing 401147, China; Corresponding authors at: Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, China.Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, China; Corresponding authors at: Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, China.To address the challenge of vertical bone augmentation in orofacial surgery and implant dentistry, this study focused on additively manufactured 3D architectural glass–ceramic scaffolds (3DP). The 3DP, which mimics the Haversian canal and trabecular porous structure, was innovatively designed and fabricated using Digital Laser Processing (DLP) additive manufacturing. The morphology, microstructure, elemental composition and mechanical characteristics of 3DP were compared with those of bovine Xenogeneic Bone Block (XBB), human Allogeneic Bone Block (ABH), and rabbit Autogenous Bone Block (ABR). Furthermore, the vertical osteogenic capacity using a rabbit calvarium model were compared among them. Micro-CT and histology analyses revealed that the osteogenic height, volume, and area of 3DP and XBB were superior to those of ABH and ABR, and 3DP demonstrated a more rapid vertical osteogenesis compared to XBB. The excellent vertical osteogenic performance of 3DP should be attributed to the ideal pore size of its microporous structure, the spatial maintaining force of its overall architecture, and its microcrystalline chemical composition after sintering. Moreover, the vertical channels in the porous network seemed to promote the rapid vertical growth of bone tissue at the early stage.http://www.sciencedirect.com/science/article/pii/S0264127525004095Vertical bone augmentationAdditive manufactured scaffold3D architectureGlass-ceramicBone-block grafts |
| spellingShingle | Wenjie Wang Lingling Zheng Wei Liu Chunjuan Wang Dan Chen Liya Ai Antonio Apicella Chao Wang Yubo Fan Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins Materials & Design Vertical bone augmentation Additive manufactured scaffold 3D architecture Glass-ceramic Bone-block grafts |
| title | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins |
| title_full | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins |
| title_fullStr | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins |
| title_full_unstemmed | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins |
| title_short | Enhanced efficacy of 3D architectural glass–ceramic scaffolds in vertical bone augmentation compared with conventional bone-block grafts of different origins |
| title_sort | enhanced efficacy of 3d architectural glass ceramic scaffolds in vertical bone augmentation compared with conventional bone block grafts of different origins |
| topic | Vertical bone augmentation Additive manufactured scaffold 3D architecture Glass-ceramic Bone-block grafts |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525004095 |
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