TNIK-driven regulation of ERK5 transcriptional activity in endothelial cells

TNIK-driven regulation of ERK5 transcriptional activity in endothelial cells

Extracellular signal-regulated kinase 5 (ERK5) is essential for cardiovascular development and endothelial cell (EC) function. Activation of ERK5 through MEK5-mediated phosphorylation at threonine 218 and tyrosine 220 (T218/Y220) drives the transcriptional activation of myocyte enhancer factor-2 (ME...

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Bibliographic Details
Main Authors: Venkata Subrahmanya Kumar Samanthapudi, Sivareddy Kotla, Nhat-Tu Le
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ERK5
TNIK
transcriptional activity
inflammation
endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1526676/full
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