Role of Pore-Forming Toxins in Neonatal Sepsis

Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease. Amo...

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Main Authors: Andreas F.-P. Sonnen, Philipp Henneke
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/608456
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author Andreas F.-P. Sonnen
Philipp Henneke
author_facet Andreas F.-P. Sonnen
Philipp Henneke
author_sort Andreas F.-P. Sonnen
collection DOAJ
description Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease. Amongst these toxins are pore-forming exotoxins that are expressed as soluble monomers prior to engagement of the target cell membrane with subsequent formation of an aqueous membrane pore. Membrane pore formation is not only a means for immediate lysis of the targeted cell but also a general mechanism that contributes to penetration of epithelial barriers and evasion of the immune system, thus creating survival niches for the pathogens. Pore-forming toxins, however, can also contribute to the induction of inflammation and hence to the manifestation of sepsis. Clearly, pore-forming toxins are not the sole factors that drive sepsis progression, but they often act in concert with other bacterial effectors, especially in the initial stages of neonatal sepsis manifestation.
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spelling doaj-art-13d66283eff544c2b5927cfdd67f1a3a2025-02-03T05:44:03ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/608456608456Role of Pore-Forming Toxins in Neonatal SepsisAndreas F.-P. Sonnen0Philipp Henneke1Center of Chronic Immunodeficiency, Medical Center, University of Freiburg, Breisacher Straße 117, 79106 Freiburg, GermanyCenter of Chronic Immunodeficiency, Medical Center, University of Freiburg, Breisacher Straße 117, 79106 Freiburg, GermanyProtein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease. Amongst these toxins are pore-forming exotoxins that are expressed as soluble monomers prior to engagement of the target cell membrane with subsequent formation of an aqueous membrane pore. Membrane pore formation is not only a means for immediate lysis of the targeted cell but also a general mechanism that contributes to penetration of epithelial barriers and evasion of the immune system, thus creating survival niches for the pathogens. Pore-forming toxins, however, can also contribute to the induction of inflammation and hence to the manifestation of sepsis. Clearly, pore-forming toxins are not the sole factors that drive sepsis progression, but they often act in concert with other bacterial effectors, especially in the initial stages of neonatal sepsis manifestation.http://dx.doi.org/10.1155/2013/608456
spellingShingle Andreas F.-P. Sonnen
Philipp Henneke
Role of Pore-Forming Toxins in Neonatal Sepsis
Clinical and Developmental Immunology
title Role of Pore-Forming Toxins in Neonatal Sepsis
title_full Role of Pore-Forming Toxins in Neonatal Sepsis
title_fullStr Role of Pore-Forming Toxins in Neonatal Sepsis
title_full_unstemmed Role of Pore-Forming Toxins in Neonatal Sepsis
title_short Role of Pore-Forming Toxins in Neonatal Sepsis
title_sort role of pore forming toxins in neonatal sepsis
url http://dx.doi.org/10.1155/2013/608456
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