Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine
Abstract Polymeric substrates can be endowed with antiviral properties by grafting N‐chloramine precursors to the surface. These surfaces bind oxidative chlorine from a dilute chlorine bleach solution and are similarly recharged after depletion for reuse. Previously, enhanced antibacterial efficacy...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-12-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202201338 |
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| author | Sarah Currie Todd Cutts Samantha Kasloff Weien Wang Kimberly Holloway Sarvesh Logsetty Anand Kumar Ayush Kumar Song Liu |
| author_facet | Sarah Currie Todd Cutts Samantha Kasloff Weien Wang Kimberly Holloway Sarvesh Logsetty Anand Kumar Ayush Kumar Song Liu |
| author_sort | Sarah Currie |
| collection | DOAJ |
| description | Abstract Polymeric substrates can be endowed with antiviral properties by grafting N‐chloramine precursors to the surface. These surfaces bind oxidative chlorine from a dilute chlorine bleach solution and are similarly recharged after depletion for reuse. Previously, enhanced antibacterial efficacy of quaternized N‐chloramines compared to their neutral counterparts is reported. In this study, a new quaternized N‐chloramine N1‐(3‐methacrylamidopropyl)‐N1,N1,N10,N10‐tetramethyl‐N10‐(2,2,6,6‐tetramethylpiperidin‐4‐yl)decane‐1,10‐diaminium (MAMPIP) featuring two quaternary ammonium groups within the structure to boost the chlorination efficiency and achieve excellent antiviral efficacy against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is reported. Antiviral fabrics are prepared by free‐radical graft polymerization of MAMPIP, or copolymerization of MAMPIP with a comonomer (acrylamide or methacrylamide) onto cotton fabrics to achieve enhanced durability to re‐chlorination. The poly(MAMPIP) grafted cotton, after chlorination, is highly effective against SARS‐CoV‐2 and achieves 4.59 log reduction (99.997%) after 5 min contact. Samples grafted with the copolymer of MAMPIP and acrylamide or methacrylamide are resistant to hydrolysis during re‐chlorination and retain high active chlorine and antiviral activity after 5 cycles of re‐chlorination (>3 log reduction after 10 min contact). Furthermore, the N‐chloramine coatings show excellent stability after exposure to simulated daylight conditions under an accelerated weathering tester, and storage for 200 days at 21 °C, 65% RH. The resulting quaternized N‐chloramine grafted cotton is a suitable platform for reusable antiviral textiles. |
| format | Article |
| id | doaj-art-13d4e99d5242489c85d482e55c2c736c |
| institution | DOAJ |
| issn | 2196-7350 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-13d4e99d5242489c85d482e55c2c736c2025-08-20T02:43:13ZengWiley-VCHAdvanced Materials Interfaces2196-73502022-12-01935n/an/a10.1002/admi.202201338Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐ChloramineSarah Currie0Todd Cutts1Samantha Kasloff2Weien Wang3Kimberly Holloway4Sarvesh Logsetty5Anand Kumar6Ayush Kumar7Song Liu8Department of Biosystems Engineering Faculty of Agricultural and Food Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 CanadaPublic Health Agency of Canada Winnipeg Manitoba R3E 3R2 CanadaPublic Health Agency of Canada Winnipeg Manitoba R3E 3R2 CanadaDepartment of Biosystems Engineering Faculty of Agricultural and Food Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 CanadaPublic Health Agency of Canada Winnipeg Manitoba R3E 3R2 CanadaDepartments of Surgery Psychiatry, Pediatrics and Child Health Rady Faculty of Health Sciences University of Manitoba Winnipeg Manitoba R3E 3P5 CanadaSections of Critical Care Medicine and Infectious Diseases University of Manitoba and Health Sciences Centre and Grace Hospital Winnipeg Manitoba R3E 3P5 CanadaDepartment of Microbiology Faculty of Science University of Manitoba Winnipeg Manitoba R3T 2N2 CanadaDepartment of Biosystems Engineering Faculty of Agricultural and Food Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 CanadaAbstract Polymeric substrates can be endowed with antiviral properties by grafting N‐chloramine precursors to the surface. These surfaces bind oxidative chlorine from a dilute chlorine bleach solution and are similarly recharged after depletion for reuse. Previously, enhanced antibacterial efficacy of quaternized N‐chloramines compared to their neutral counterparts is reported. In this study, a new quaternized N‐chloramine N1‐(3‐methacrylamidopropyl)‐N1,N1,N10,N10‐tetramethyl‐N10‐(2,2,6,6‐tetramethylpiperidin‐4‐yl)decane‐1,10‐diaminium (MAMPIP) featuring two quaternary ammonium groups within the structure to boost the chlorination efficiency and achieve excellent antiviral efficacy against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is reported. Antiviral fabrics are prepared by free‐radical graft polymerization of MAMPIP, or copolymerization of MAMPIP with a comonomer (acrylamide or methacrylamide) onto cotton fabrics to achieve enhanced durability to re‐chlorination. The poly(MAMPIP) grafted cotton, after chlorination, is highly effective against SARS‐CoV‐2 and achieves 4.59 log reduction (99.997%) after 5 min contact. Samples grafted with the copolymer of MAMPIP and acrylamide or methacrylamide are resistant to hydrolysis during re‐chlorination and retain high active chlorine and antiviral activity after 5 cycles of re‐chlorination (>3 log reduction after 10 min contact). Furthermore, the N‐chloramine coatings show excellent stability after exposure to simulated daylight conditions under an accelerated weathering tester, and storage for 200 days at 21 °C, 65% RH. The resulting quaternized N‐chloramine grafted cotton is a suitable platform for reusable antiviral textiles.https://doi.org/10.1002/admi.202201338antimicrobial textilesantiviralCOVID‐19N‐chloramineSARS‐CoV‐2 |
| spellingShingle | Sarah Currie Todd Cutts Samantha Kasloff Weien Wang Kimberly Holloway Sarvesh Logsetty Anand Kumar Ayush Kumar Song Liu Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine Advanced Materials Interfaces antimicrobial textiles antiviral COVID‐19 N‐chloramine SARS‐CoV‐2 |
| title | Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine |
| title_full | Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine |
| title_fullStr | Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine |
| title_full_unstemmed | Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine |
| title_short | Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine |
| title_sort | rechargeable potent anti viral cotton grafted with a new quaternized n chloramine |
| topic | antimicrobial textiles antiviral COVID‐19 N‐chloramine SARS‐CoV‐2 |
| url | https://doi.org/10.1002/admi.202201338 |
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