Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21
In the ground sealed station crew, during the 8 months international experiment SIRIUS 20/21 simulating an interplanetary flight, electrically induced phosphene (EIP) thresholds, which reflected the electrical sensitivity (ES) of the retina, and the optic nerve. ES&L was assessed using the “...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ophthalmology Publishing Group
2023-07-01
|
| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/2106 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849240854950051840 |
|---|---|
| author | V. V. Neroev M. V. Zueva V. I. Kotelin O. M. Manko I. V. Egorova I. V. Tsapenko A. M. Aleskerov D. A. Podyanov |
| author_facet | V. V. Neroev M. V. Zueva V. I. Kotelin O. M. Manko I. V. Egorova I. V. Tsapenko A. M. Aleskerov D. A. Podyanov |
| author_sort | V. V. Neroev |
| collection | DOAJ |
| description | In the ground sealed station crew, during the 8 months international experiment SIRIUS 20/21 simulating an interplanetary flight, electrically induced phosphene (EIP) thresholds, which reflected the electrical sensitivity (ES) of the retina, and the optic nerve. ES&L was assessed using the “ESOM” device (“Neuron”, Ufa, Russia) once a month, twice a day (morning/evening), under mesopic conditions. An increase in ES and other patterns of changes in ES&L parameters during period of isolation were established, reflecting the adaptation of the crew to the conditions of the experiment and the reaction of the visual system to physical and psycho-emotional stress. Further study of the thresholds of the EIP and L of the optic nerve in experiments of increasing duration will make it possible to determine the biomarkers that differentiate the individual adaptive reaction of astronauts from dysfunction of the retina and optic nerve under real space flight conditions. The L of the optic nerve showed greater resistance to experimental conditions than the ES of the retina. The results suggest that the determination of the L in the ES&L test can become an express test on board the ISS to assess the functional state of the papillomacular bundle of optic nerve fibers, the risk of developing or diagnosing SANS (flight-associated neuro-ocular syndrome) in long-term space missions. |
| format | Article |
| id | doaj-art-13d3e6bee5144b369f1dcfea74d10771 |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-13d3e6bee5144b369f1dcfea74d107712025-08-20T04:00:25ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452023-07-0120226627510.18008/1816-5095-2023-2-266-2751027Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21V. V. Neroev0M. V. Zueva1V. I. Kotelin2O. M. Manko3I. V. Egorova4I. V. Tsapenko5A. M. Aleskerov6D. A. Podyanov7Helmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesInstitute for Biomedical Problems of the Russian Academy of SciencesHelmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesInstitute for Biomedical Problems of the Russian Academy of SciencesInstitute for Biomedical Problems of the Russian Academy of SciencesIn the ground sealed station crew, during the 8 months international experiment SIRIUS 20/21 simulating an interplanetary flight, electrically induced phosphene (EIP) thresholds, which reflected the electrical sensitivity (ES) of the retina, and the optic nerve. ES&L was assessed using the “ESOM” device (“Neuron”, Ufa, Russia) once a month, twice a day (morning/evening), under mesopic conditions. An increase in ES and other patterns of changes in ES&L parameters during period of isolation were established, reflecting the adaptation of the crew to the conditions of the experiment and the reaction of the visual system to physical and psycho-emotional stress. Further study of the thresholds of the EIP and L of the optic nerve in experiments of increasing duration will make it possible to determine the biomarkers that differentiate the individual adaptive reaction of astronauts from dysfunction of the retina and optic nerve under real space flight conditions. The L of the optic nerve showed greater resistance to experimental conditions than the ES of the retina. The results suggest that the determination of the L in the ES&L test can become an express test on board the ISS to assess the functional state of the papillomacular bundle of optic nerve fibers, the risk of developing or diagnosing SANS (flight-associated neuro-ocular syndrome) in long-term space missions.https://www.ophthalmojournal.com/opht/article/view/2106retinal electrical sensitivityphospheneoptic nerve labilitydiagnostics of retinal and optic nerve dysfunctionsirius |
| spellingShingle | V. V. Neroev M. V. Zueva V. I. Kotelin O. M. Manko I. V. Egorova I. V. Tsapenko A. M. Aleskerov D. A. Podyanov Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 Oftalʹmologiâ retinal electrical sensitivity phosphene optic nerve lability diagnostics of retinal and optic nerve dysfunction sirius |
| title | Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 |
| title_full | Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 |
| title_fullStr | Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 |
| title_full_unstemmed | Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 |
| title_short | Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21 |
| title_sort | changes in thresholds of electrically evoked phosphene and electrical lability of the optic nerve in the ground station crew in the international experiment sirius 20 21 |
| topic | retinal electrical sensitivity phosphene optic nerve lability diagnostics of retinal and optic nerve dysfunction sirius |
| url | https://www.ophthalmojournal.com/opht/article/view/2106 |
| work_keys_str_mv | AT vvneroev changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT mvzueva changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT vikotelin changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT ommanko changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT ivegorova changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT ivtsapenko changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT amaleskerov changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 AT dapodyanov changesinthresholdsofelectricallyevokedphospheneandelectricallabilityoftheopticnerveinthegroundstationcrewintheinternationalexperimentsirius2021 |