Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis
Abstract Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various chronic diseases in the future. The systemic immune-inflammation index (SII) serves as an indicator of inflammation and immune response. Thi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-91125-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191228323233792 |
|---|---|
| author | Yu-zhen Zhang Run-wei Ma Suwas Bhandari Juan Xie Xiao-yu Zhang Chao Xie Hong Duan Juan Meng Qiong-yu Wu Kai Liu Bo Feng Li-ming Cheng |
| author_facet | Yu-zhen Zhang Run-wei Ma Suwas Bhandari Juan Xie Xiao-yu Zhang Chao Xie Hong Duan Juan Meng Qiong-yu Wu Kai Liu Bo Feng Li-ming Cheng |
| author_sort | Yu-zhen Zhang |
| collection | DOAJ |
| description | Abstract Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various chronic diseases in the future. The systemic immune-inflammation index (SII) serves as an indicator of inflammation and immune response. This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, including 5,676 participants. A multivariate logistic regression model, Generalized Additive Models (GAM), and subgroup analysis were used to examine the relationship between obesity and SII. The multivariate logistic regression results revealed a significant positive correlation between log SII and adolescent obesity (1.254 [1.024–1.537]). Furthermore, the risk of obesity increased with higher quartiles of SII. Subgroup analysis and interaction tests showed that this positive association persisted across various factors, including female gender, race (Non-Hispanic White and Mexican American), non-hyperlipidemia, normal white blood cell count, and PIR < 1. Additionally, a U-shaped relationship between log SII and obesity was observed, with a turning point at 6.410. The findings suggest that an increase in the systemic immune-inflammation index is significantly associated with obesity in adolescents. However, further validation through large-scale prospective studies is needed. |
| format | Article |
| id | doaj-art-13d05dfad36644dfbc6e51811d3386fb |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-13d05dfad36644dfbc6e51811d3386fb2025-08-20T02:14:59ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-91125-6Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysisYu-zhen Zhang0Run-wei Ma1Suwas Bhandari2Juan Xie3Xiao-yu Zhang4Chao Xie5Hong Duan6Juan Meng7Qiong-yu Wu8Kai Liu9Bo Feng10Li-ming Cheng11Department of Anesthesiology, Kunming Children’s HospitalDepartment of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical UniversityWenzhou Medical UniversityDepartment of Comprehensive Pediatrics, Kunming Children’s HospitalDepartment of Cardiac Surgery, The First People’s Hospital of KunmingSurgical Intensive Care Unit, Kunming Children’s HospitalSurgical Intensive Care Unit, Kunming Children’s HospitalDepartment of Anesthesiology, Kunming City Maternal and Child Health HospitalDepartment of Anesthesiology, Kunming Children’s HospitalDepartment of Comprehensive Pediatrics, Kunming Children’s HospitalDepartment of Anesthesiology, Kunming Children’s HospitalDepartment of Anesthesiology, Kunming Children’s HospitalAbstract Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various chronic diseases in the future. The systemic immune-inflammation index (SII) serves as an indicator of inflammation and immune response. This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, including 5,676 participants. A multivariate logistic regression model, Generalized Additive Models (GAM), and subgroup analysis were used to examine the relationship between obesity and SII. The multivariate logistic regression results revealed a significant positive correlation between log SII and adolescent obesity (1.254 [1.024–1.537]). Furthermore, the risk of obesity increased with higher quartiles of SII. Subgroup analysis and interaction tests showed that this positive association persisted across various factors, including female gender, race (Non-Hispanic White and Mexican American), non-hyperlipidemia, normal white blood cell count, and PIR < 1. Additionally, a U-shaped relationship between log SII and obesity was observed, with a turning point at 6.410. The findings suggest that an increase in the systemic immune-inflammation index is significantly associated with obesity in adolescents. However, further validation through large-scale prospective studies is needed.https://doi.org/10.1038/s41598-025-91125-6Systemic immune-inflammation indexAdolescent obesityNHANESInflammation |
| spellingShingle | Yu-zhen Zhang Run-wei Ma Suwas Bhandari Juan Xie Xiao-yu Zhang Chao Xie Hong Duan Juan Meng Qiong-yu Wu Kai Liu Bo Feng Li-ming Cheng Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis Scientific Reports Systemic immune-inflammation index Adolescent obesity NHANES Inflammation |
| title | Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis |
| title_full | Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis |
| title_fullStr | Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis |
| title_full_unstemmed | Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis |
| title_short | Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis |
| title_sort | association between systemic immune inflammation index and adolescent obesity in a cross sectional analysis |
| topic | Systemic immune-inflammation index Adolescent obesity NHANES Inflammation |
| url | https://doi.org/10.1038/s41598-025-91125-6 |
| work_keys_str_mv | AT yuzhenzhang associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT runweima associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT suwasbhandari associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT juanxie associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT xiaoyuzhang associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT chaoxie associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT hongduan associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT juanmeng associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT qiongyuwu associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT kailiu associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT bofeng associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis AT limingcheng associationbetweensystemicimmuneinflammationindexandadolescentobesityinacrosssectionalanalysis |