Schottky barrier in pea-like Au@Bi2S3 nanoreactor enabling efficient photodynamic therapy of hepatocellular carcinoma

Schottky barrier in pea-like Au@Bi2S3 nanoreactor enabling efficient photodynamic therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC), a leading cause of tumor-related mortality globally, demands innovative therapeutic strategies to overcome limitations of conventional treatments. Photodynamic therapy (PDT), reliant on reactive oxygen species (ROS) generation, has emerged as a promising therapeutic s...

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Main Authors: Liangsong Tao, Rongrong Gu, Junfa Yang, Jiewei Wang, Tiling Wu, Xianyue Rao, Hao Wang, Cheng Qian, Jian Liu, Sheng Ye, Tao Xu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Nanoreactor
Schottky barrier
Reactive oxygen species
Hepatocellular carcinoma
Hippo/Yap signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642500571X
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Summary:Hepatocellular carcinoma (HCC), a leading cause of tumor-related mortality globally, demands innovative therapeutic strategies to overcome limitations of conventional treatments. Photodynamic therapy (PDT), reliant on reactive oxygen species (ROS) generation, has emerged as a promising therapeutic strategy for neoplastic diseases. But it is constrained by inefficient charge separation in traditional photosensitizers. Here, we engineered a pea-like Au@Bi2S3 nanoreactors by anchoring gold nanoparticles onto Bi2S3 surfaces to establish a Schottky junction with interfacial Au-S covalent bonds, which suppresses electron-hole recombination and amplifies ROS production. Under light irradiation, Au@Bi2S3 exhibited remarkable inhibitory efficacy against HepG-2 cells, producing twice the ROS yield of Bi2S3. Transcriptomic analysis via RNA sequencing identified activation of the Hippo/Yap signaling pathway, which orchestrated endoplasmic reticulum stress and autophagic flux in malignant cells, ultimately driving apoptotic elimination of HepG-2 populations. These findings delineate a mechanistic paradigm wherein Schottky junction engineering potentiates ROS-mediated cytotoxicity, thereby advancing precise photodynamic interventions for HCC management.
ISSN:2590-0064

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