CK2α Deletion in the Hematopoietic Compartment Shows a Mild Alteration in Terminally Differentiated Cells and the Expansion of Stem Cells

CK2α Deletion in the Hematopoietic Compartment Shows a Mild Alteration in Terminally Differentiated Cells and the Expansion of Stem Cells

Casein Kinase II (CK2) is a ubiquitously present serine/threonine kinase essential for mammalian development. CK2 holoenzyme is a tetramer with two highly related catalytic subunits (α or α’) and two regulatory ß subunits. Global deletion of the α or β subunit in mice is embryonically lethal. We and...

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Main Authors: Rajesh Rajaiah, Muhammad Daniyal, Marudhu Pandiyan Shanmugam, Hannah Valensi, Koby Duke, Katherine Mercer, Morgann Klink, Matthew Lanza, Yasin Uzun, Suming Huang, Sinisa Dovat, Chandrika Gowda Behura
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
casein kinase 2
normal hematopoiesis
hematopoietic stem cells
Vav iCre
conditional knockout
CK2alpha
Online Access:https://www.mdpi.com/2073-4409/14/13/963
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