Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation
Background. Alterations in blood coagulation and fibrinolysis are believed to play an important role in the pathogenesis of preeclampsia. Hypercoagulability may be associated with features seen in preeclampsia, such as fibrin deposition in various organs, consumptive thrombocytopenia, and placental...
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| Language: | English |
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Wiley
1997-06-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.3109/00016349709024580 |
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| author | Rune Schjetlein Guttorm Haugen Finn Wisløff |
| author_facet | Rune Schjetlein Guttorm Haugen Finn Wisløff |
| author_sort | Rune Schjetlein |
| collection | DOAJ |
| description | Background. Alterations in blood coagulation and fibrinolysis are believed to play an important role in the pathogenesis of preeclampsia. Hypercoagulability may be associated with features seen in preeclampsia, such as fibrin deposition in various organs, consumptive thrombocytopenia, and placental hypoperfusion, insufficiency and infarction. Methods. In this cohort study, we compared the plasma levels of markers of blood coagulation and fibrinolysis in preeclamptic women to normotensive, pregnant controls. We also studied the association between these markers and intrauterine growth retardation (IUGR). Results. In both mild and severe preeclampsia, the mean plasma concentrations of thrombin‐antithrombin III complex (TAT) and plasminogen activator inhibitor type 1 (PAI‐1) activity were significantly increased, while fibrinogen, antithrombin III (ATIII) and plasminogen activator inhibitor type‐2 (PAI‐2) antigen levels were significantly reduced compared to controls. Plasma D‐dimer concentration was significantly higher in severe, but not in mild preeclampsia compared to the controls. The plasma level of fibrin monomer was similar in patients and controls. Patients with preeclampsia delivering growth retarded infants had significantly lower PAI‐1 activity and PAI‐2 antigen concentrations in plasma than the remaining preeclamptic women. Conclusions. We found evidence of increased intravascular coagulation and fibrin turnover in preeclampsia. Low PAI‐2 antigen plasma levels were associated with severe preeclampsia and IUGR. |
| format | Article |
| id | doaj-art-13c5d1104ceb436bbe4f2b5df104f0a0 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 1997-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-13c5d1104ceb436bbe4f2b5df104f0a02025-08-20T02:37:32ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04121997-06-0176654154610.3109/00016349709024580Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardationRune Schjetlein0Guttorm Haugen1Finn Wisløff2Hematological Research Laboratory, Ullevål Hospital, NorwayDepartment of Obstetrics and Gynecology, The National Hospital, University of Oslo, NorwayHematological Research Laboratory, Ullevål Hospital, NorwayBackground. Alterations in blood coagulation and fibrinolysis are believed to play an important role in the pathogenesis of preeclampsia. Hypercoagulability may be associated with features seen in preeclampsia, such as fibrin deposition in various organs, consumptive thrombocytopenia, and placental hypoperfusion, insufficiency and infarction. Methods. In this cohort study, we compared the plasma levels of markers of blood coagulation and fibrinolysis in preeclamptic women to normotensive, pregnant controls. We also studied the association between these markers and intrauterine growth retardation (IUGR). Results. In both mild and severe preeclampsia, the mean plasma concentrations of thrombin‐antithrombin III complex (TAT) and plasminogen activator inhibitor type 1 (PAI‐1) activity were significantly increased, while fibrinogen, antithrombin III (ATIII) and plasminogen activator inhibitor type‐2 (PAI‐2) antigen levels were significantly reduced compared to controls. Plasma D‐dimer concentration was significantly higher in severe, but not in mild preeclampsia compared to the controls. The plasma level of fibrin monomer was similar in patients and controls. Patients with preeclampsia delivering growth retarded infants had significantly lower PAI‐1 activity and PAI‐2 antigen concentrations in plasma than the remaining preeclamptic women. Conclusions. We found evidence of increased intravascular coagulation and fibrin turnover in preeclampsia. Low PAI‐2 antigen plasma levels were associated with severe preeclampsia and IUGR.https://doi.org/10.3109/00016349709024580coagulationfibrinolysisintrauterine growth retardationpreeclampsia |
| spellingShingle | Rune Schjetlein Guttorm Haugen Finn Wisløff Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation Acta Obstetricia et Gynecologica Scandinavica coagulation fibrinolysis intrauterine growth retardation preeclampsia |
| title | Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation |
| title_full | Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation |
| title_fullStr | Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation |
| title_full_unstemmed | Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation |
| title_short | Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation |
| title_sort | markers of intravascular coagulation and fibrinolysis in preeclampsia association with intrauterine growth retardation |
| topic | coagulation fibrinolysis intrauterine growth retardation preeclampsia |
| url | https://doi.org/10.3109/00016349709024580 |
| work_keys_str_mv | AT runeschjetlein markersofintravascularcoagulationandfibrinolysisinpreeclampsiaassociationwithintrauterinegrowthretardation AT guttormhaugen markersofintravascularcoagulationandfibrinolysisinpreeclampsiaassociationwithintrauterinegrowthretardation AT finnwisløff markersofintravascularcoagulationandfibrinolysisinpreeclampsiaassociationwithintrauterinegrowthretardation |