The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise
Obesity is a major global health epidemic. Obesity and its associated comorbidities diminish the quality of life and have negative financial impacts. Obesity is a complex disease that involves the interplay of different metabolic pathways in multiple tissues and organs of the body. Leptin, secreted...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Advanced Exercise and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950273X25000025 |
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| author | Qura Tul Ain Melpomeni Malamouli Deanne H. Hryciw |
| author_facet | Qura Tul Ain Melpomeni Malamouli Deanne H. Hryciw |
| author_sort | Qura Tul Ain |
| collection | DOAJ |
| description | Obesity is a major global health epidemic. Obesity and its associated comorbidities diminish the quality of life and have negative financial impacts. Obesity is a complex disease that involves the interplay of different metabolic pathways in multiple tissues and organs of the body. Leptin, secreted by adipocytes, plays a crucial role in energy homeostasis via its ability to modulate function in peripheral metabolic tissues such as adipose tissue, liver, pancreas, and skeletal muscles, with dysfunction impacting energy homeostasis. The endocannabinoid system (ECS) is an endogenous signaling system involved in food intake and peripheral energy homeostasis and appears to be dysfunctional in obesity. Dietary intake of polyunsaturated fatty acids especially linoleic acid has increased dramatically over the last few decades. Excessive intake of linoleic acid in the diet can lead to an increase in the endogenous ligands that modulate the ECS contributing to the metabolic dysfunction. Regular physical activity is a key lifestyle factor that assists with the management of obesity. This review will focus on exploring the existing evidence about the interaction of leptin and the ECS and how exercise and linoleic acid affects their regulation in peripheral metabolic organs such as adipose tissues, liver, pancreas and skeletal muscles. |
| format | Article |
| id | doaj-art-13c50a5f5a2944f2aac870c3efeeefb5 |
| institution | OA Journals |
| issn | 2950-273X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Advanced Exercise and Health Science |
| spelling | doaj-art-13c50a5f5a2944f2aac870c3efeeefb52025-08-20T02:06:08ZengKeAi Communications Co., Ltd.Advanced Exercise and Health Science2950-273X2025-03-0121243210.1016/j.aehs.2025.01.001The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exerciseQura Tul Ain0Melpomeni Malamouli1Deanne H. Hryciw2Institute for Health and Sport, Victoria University, Melbourne, AustraliaInstitute for Health and Sport, Victoria University, Melbourne, AustraliaSchool of Environment and Science, Griffith University, Nathan, Australia; Institute for Biomedicine and Glycomics, Griffith University, Nathan, Australia; Corresponding author at: School of Environment and Science, Griffith University, Nathan, AustraliaObesity is a major global health epidemic. Obesity and its associated comorbidities diminish the quality of life and have negative financial impacts. Obesity is a complex disease that involves the interplay of different metabolic pathways in multiple tissues and organs of the body. Leptin, secreted by adipocytes, plays a crucial role in energy homeostasis via its ability to modulate function in peripheral metabolic tissues such as adipose tissue, liver, pancreas, and skeletal muscles, with dysfunction impacting energy homeostasis. The endocannabinoid system (ECS) is an endogenous signaling system involved in food intake and peripheral energy homeostasis and appears to be dysfunctional in obesity. Dietary intake of polyunsaturated fatty acids especially linoleic acid has increased dramatically over the last few decades. Excessive intake of linoleic acid in the diet can lead to an increase in the endogenous ligands that modulate the ECS contributing to the metabolic dysfunction. Regular physical activity is a key lifestyle factor that assists with the management of obesity. This review will focus on exploring the existing evidence about the interaction of leptin and the ECS and how exercise and linoleic acid affects their regulation in peripheral metabolic organs such as adipose tissues, liver, pancreas and skeletal muscles.http://www.sciencedirect.com/science/article/pii/S2950273X25000025EndocannabinoidsObesityExerciseLinoleic acid |
| spellingShingle | Qura Tul Ain Melpomeni Malamouli Deanne H. Hryciw The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise Advanced Exercise and Health Science Endocannabinoids Obesity Exercise Linoleic acid |
| title | The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise |
| title_full | The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise |
| title_fullStr | The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise |
| title_full_unstemmed | The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise |
| title_short | The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise |
| title_sort | interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity modulation by linoleic acid and exercise |
| topic | Endocannabinoids Obesity Exercise Linoleic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2950273X25000025 |
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