The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity, Modulation by linoleic acid and exercise
Obesity is a major global health epidemic. Obesity and its associated comorbidities diminish the quality of life and have negative financial impacts. Obesity is a complex disease that involves the interplay of different metabolic pathways in multiple tissues and organs of the body. Leptin, secreted...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Advanced Exercise and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950273X25000025 |
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| Summary: | Obesity is a major global health epidemic. Obesity and its associated comorbidities diminish the quality of life and have negative financial impacts. Obesity is a complex disease that involves the interplay of different metabolic pathways in multiple tissues and organs of the body. Leptin, secreted by adipocytes, plays a crucial role in energy homeostasis via its ability to modulate function in peripheral metabolic tissues such as adipose tissue, liver, pancreas, and skeletal muscles, with dysfunction impacting energy homeostasis. The endocannabinoid system (ECS) is an endogenous signaling system involved in food intake and peripheral energy homeostasis and appears to be dysfunctional in obesity. Dietary intake of polyunsaturated fatty acids especially linoleic acid has increased dramatically over the last few decades. Excessive intake of linoleic acid in the diet can lead to an increase in the endogenous ligands that modulate the ECS contributing to the metabolic dysfunction. Regular physical activity is a key lifestyle factor that assists with the management of obesity. This review will focus on exploring the existing evidence about the interaction of leptin and the ECS and how exercise and linoleic acid affects their regulation in peripheral metabolic organs such as adipose tissues, liver, pancreas and skeletal muscles. |
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| ISSN: | 2950-273X |