Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq
Background: Melatonin has been shown to directly affect metabolism and body weight management, in addition to its established involvement in circadian rhythm. Objectives: We aimed to investigate the relationship between serum melatonin and adult BMI, serum insulin, and lipid profile (cholesterol, hi...
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_787_24 |
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| author | Anwar Kawther Ali Ekhlas Hatem Abd_Alameer Qais Ismaeel Kadhem |
| author_facet | Anwar Kawther Ali Ekhlas Hatem Abd_Alameer Qais Ismaeel Kadhem |
| author_sort | Anwar Kawther Ali |
| collection | DOAJ |
| description | Background: Melatonin has been shown to directly affect metabolism and body weight management, in addition to its established involvement in circadian rhythm. Objectives: We aimed to investigate the relationship between serum melatonin and adult BMI, serum insulin, and lipid profile (cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and TG). Materials and Methods: In this cross-sectional study, 150 individuals (78 females and 72 males) aged 18–60 were recruited. Samples were collected at Imam al-Sadiq Hospital and Marjan Hospital in Babylon Governorate from September 1, 2023, to June 30, 2024. Patients’ metabolic blood parameters, such as insulin, triglycerides, HDL, LDL, HB, urea, creatinine, and cholesterol, were measured and their association with serum melatonin determined. Results: This study included a total of (150) patients, with the mean age of participants (32.0 ± 7.9) years and a median age of (31) years. Regarding gender distribution, the proportion of female patients was 52.0% compared to males (48.0%). Mean BMI of study patients was (30.6 ± 8.3) kg/m2. The majority (60.7%) of patients were obese (BMI ≥ 30). There was a significant difference among age groups, with a P value of 0.006. Comparison between males and females regarding serum melatonin level indicated that there were no significant differences between them. In a similar manner, no significant difference was observed between urban residents (11.7 ± 11.7) and rural residents (26.9 ± 10.7). Conclusion: A correlation was observed between insulin resistance and melatonin secretion; groups with elevated BMI with higher melatonin levels also had higher insulin resistance. Also, higher melatonin concentrations in the serum, insulin excess (overweight), and a high lipid profile, along with low vitamin D, were observed. The high BMI group has low vitamin D, whereas normal BMI group has normal vitamin D. Thus, overweight (high BMI) people tend to have lower vitamin D levels. |
| format | Article |
| id | doaj-art-13bfdecef6fb4320afebea2f210a06af |
| institution | OA Journals |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-13bfdecef6fb4320afebea2f210a06af2025-08-20T01:51:41ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602025-01-0122130531010.4103/MJBL.MJBL_787_24Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, IraqAnwar Kawther AliEkhlas Hatem Abd_AlameerQais Ismaeel KadhemBackground: Melatonin has been shown to directly affect metabolism and body weight management, in addition to its established involvement in circadian rhythm. Objectives: We aimed to investigate the relationship between serum melatonin and adult BMI, serum insulin, and lipid profile (cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and TG). Materials and Methods: In this cross-sectional study, 150 individuals (78 females and 72 males) aged 18–60 were recruited. Samples were collected at Imam al-Sadiq Hospital and Marjan Hospital in Babylon Governorate from September 1, 2023, to June 30, 2024. Patients’ metabolic blood parameters, such as insulin, triglycerides, HDL, LDL, HB, urea, creatinine, and cholesterol, were measured and their association with serum melatonin determined. Results: This study included a total of (150) patients, with the mean age of participants (32.0 ± 7.9) years and a median age of (31) years. Regarding gender distribution, the proportion of female patients was 52.0% compared to males (48.0%). Mean BMI of study patients was (30.6 ± 8.3) kg/m2. The majority (60.7%) of patients were obese (BMI ≥ 30). There was a significant difference among age groups, with a P value of 0.006. Comparison between males and females regarding serum melatonin level indicated that there were no significant differences between them. In a similar manner, no significant difference was observed between urban residents (11.7 ± 11.7) and rural residents (26.9 ± 10.7). Conclusion: A correlation was observed between insulin resistance and melatonin secretion; groups with elevated BMI with higher melatonin levels also had higher insulin resistance. Also, higher melatonin concentrations in the serum, insulin excess (overweight), and a high lipid profile, along with low vitamin D, were observed. The high BMI group has low vitamin D, whereas normal BMI group has normal vitamin D. Thus, overweight (high BMI) people tend to have lower vitamin D levels.https://doi.org/10.4103/MJBL.MJBL_787_24bmilipid profilemelatoninobesityserum insulin |
| spellingShingle | Anwar Kawther Ali Ekhlas Hatem Abd_Alameer Qais Ismaeel Kadhem Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq Medical Journal of Babylon bmi lipid profile melatonin obesity serum insulin |
| title | Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq |
| title_full | Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq |
| title_fullStr | Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq |
| title_full_unstemmed | Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq |
| title_short | Association of Body Mass, Serum Insulin, and Lipid Profile with Serum Melatonin Levels in Individuals in Babylon, Iraq |
| title_sort | association of body mass serum insulin and lipid profile with serum melatonin levels in individuals in babylon iraq |
| topic | bmi lipid profile melatonin obesity serum insulin |
| url | https://doi.org/10.4103/MJBL.MJBL_787_24 |
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