Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer
INTRODUCTION. A number of studies demonstrate the advantage of bilateral mediastinal lymphadenectomy in surgery of non-small cell lung cancer (nSCLC). For surgical approach to the opposite mediastinum for many years there were proposed sternotomy, video-thoracoscopy, and transcervical video-assisted...
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Pavlov First Saint Petersburg State Medical University
2021-04-01
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| Series: | Вестник хирургии имени И.И. Грекова |
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| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/1632 |
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| author | A. A. Skorokhod A. S. Petrov A. R. Kozak M. A. Atyukov A. O. Nefedov P. K. Yаblonskiy |
| author_facet | A. A. Skorokhod A. S. Petrov A. R. Kozak M. A. Atyukov A. O. Nefedov P. K. Yаblonskiy |
| author_sort | A. A. Skorokhod |
| collection | DOAJ |
| description | INTRODUCTION. A number of studies demonstrate the advantage of bilateral mediastinal lymphadenectomy in surgery of non-small cell lung cancer (nSCLC). For surgical approach to the opposite mediastinum for many years there were proposed sternotomy, video-thoracoscopy, and transcervical video-assisted interventions. In our practice, we use videoassisted mediastinal lymphadenectomy (VAMLA).The OBJECTIVE was to learn the efficiency and safety of VAMLA in surgery of NSCLC.METHODS AND MATERIALS. The study included the materials of examination and treatment of 102 patients with NSCLC. 102 patients were divided into 2 groups. In the 1st group (54 patients), VAMLA and lung resection were performed. In the 2nd group (48 patients): anatomical lung resection and systematic ipsilateral lymphadenectomy (SLD) were performed.RESULTS. The average number of remote lymph node stations in group 1 was (7.8±1.7); in group 2 – (4.5±1.2) (p<0.05). The average number of lymph nodes was 26±8.6 compared to (14.3±6) in both groups, respectively (p<0.05). «Occult» pN2-N3 metastasis was detected in 20 % (7/34) of patients of the group 1 and 6.5 % (2/31) of patients of the group 2 (p<0.05). The level of postoperative complications in both groups was 33.4 vs. 29.2 %, respectively (p>0.05). The duration of the postoperative day ((12.7±4.9) vs. (13.7±6.5)) and the duration of pleural drainage ((5.5±4.2) vs. (5.8±4.4)) did not differ in both groups (p>0.05).CONCLUSION. VAMLA is an effective and safe method for evaluating the pN stage of NSCLC. Performing VAMLA in left-sided NSCLC allows removing significantly more lymph nodes and stations in comparison with SLD available in VATS and thoracotomy, which increases the accuracy of postoperative N-staging. The use of the VAMLA in minimally invasive surgery of right-sided NSCLC may be promising in cases of high risk of «occult» pN3 lesion, but requires further study of the role of contralateral lymphatic dissection. |
| format | Article |
| id | doaj-art-13bea76a88434d24a50bbfc079ccbf61 |
| institution | Kabale University |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-13bea76a88434d24a50bbfc079ccbf612025-08-20T04:00:33ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252021-04-011796243310.24884/0042-4625-2020-179-6-24-331214Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancerA. A. Skorokhod0A. S. Petrov1A. R. Kozak2M. A. Atyukov3A. O. Nefedov4P. K. Yаblonskiy5Saint Petersburg Research Institute of Phthisiopulmonology; City multidisciplinary hospital № 2City multidisciplinary hospital № 2; Saint Petersburg State UniversitySaint Petersburg Research Institute of PhthisiopulmonologyCity multidisciplinary hospital № 2Saint Petersburg Research Institute of PhthisiopulmonologySaint Petersburg Research Institute of Phthisiopulmonology; Saint Petersburg State UniversityINTRODUCTION. A number of studies demonstrate the advantage of bilateral mediastinal lymphadenectomy in surgery of non-small cell lung cancer (nSCLC). For surgical approach to the opposite mediastinum for many years there were proposed sternotomy, video-thoracoscopy, and transcervical video-assisted interventions. In our practice, we use videoassisted mediastinal lymphadenectomy (VAMLA).The OBJECTIVE was to learn the efficiency and safety of VAMLA in surgery of NSCLC.METHODS AND MATERIALS. The study included the materials of examination and treatment of 102 patients with NSCLC. 102 patients were divided into 2 groups. In the 1st group (54 patients), VAMLA and lung resection were performed. In the 2nd group (48 patients): anatomical lung resection and systematic ipsilateral lymphadenectomy (SLD) were performed.RESULTS. The average number of remote lymph node stations in group 1 was (7.8±1.7); in group 2 – (4.5±1.2) (p<0.05). The average number of lymph nodes was 26±8.6 compared to (14.3±6) in both groups, respectively (p<0.05). «Occult» pN2-N3 metastasis was detected in 20 % (7/34) of patients of the group 1 and 6.5 % (2/31) of patients of the group 2 (p<0.05). The level of postoperative complications in both groups was 33.4 vs. 29.2 %, respectively (p>0.05). The duration of the postoperative day ((12.7±4.9) vs. (13.7±6.5)) and the duration of pleural drainage ((5.5±4.2) vs. (5.8±4.4)) did not differ in both groups (p>0.05).CONCLUSION. VAMLA is an effective and safe method for evaluating the pN stage of NSCLC. Performing VAMLA in left-sided NSCLC allows removing significantly more lymph nodes and stations in comparison with SLD available in VATS and thoracotomy, which increases the accuracy of postoperative N-staging. The use of the VAMLA in minimally invasive surgery of right-sided NSCLC may be promising in cases of high risk of «occult» pN3 lesion, but requires further study of the role of contralateral lymphatic dissection.https://www.vestnik-grekova.ru/jour/article/view/1632video-assisted mediastinal lymphadenectomyvamlabilateral lymphatic dissectionnon-small cell lung cancerlung resectionsurgical treatment |
| spellingShingle | A. A. Skorokhod A. S. Petrov A. R. Kozak M. A. Atyukov A. O. Nefedov P. K. Yаblonskiy Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer Вестник хирургии имени И.И. Грекова video-assisted mediastinal lymphadenectomy vamla bilateral lymphatic dissection non-small cell lung cancer lung resection surgical treatment |
| title | Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer |
| title_full | Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer |
| title_fullStr | Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer |
| title_full_unstemmed | Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer |
| title_short | Efficiency and safety of video-assisted mediastinal lymphadenectomy in the treatment of non-small cell lung cancer |
| title_sort | efficiency and safety of video assisted mediastinal lymphadenectomy in the treatment of non small cell lung cancer |
| topic | video-assisted mediastinal lymphadenectomy vamla bilateral lymphatic dissection non-small cell lung cancer lung resection surgical treatment |
| url | https://www.vestnik-grekova.ru/jour/article/view/1632 |
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