SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.

Human Cytomegalovirus (HCMV) is a commonly infected double-stranded DNA virus of the β-herpesviridae subfamily that typically establishes lifelong latency or persistent infection following primary infection. The regulation of HCMV latency and reactivation is governed by the chromatin structure at th...

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Bibliographic Details
Main Authors: Sisi Xia, Xiaoping Huo, Nanfang Liu, Xinyu Liu, Tianyou Wang, Muyi Guo, Chi Zeng, Pin Wan, Jun Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013344
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