Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022
In the spring 2022, the number of cases of severe acute hepatitis of unknown etiology was unusual increased in Europe. As an immediate response, the World health organization recommended active efforts to identify such cases at the international level. For monitoring of acute hepatitis in Moscow, pa...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2024-11-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/994 |
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| author | М. А. Sayfullin L. N. Mazankova A. Yu. Rtischev E. N. Abramova N. A. Antypyat N. N. Zvereva O. A. Ivanova M. A. Kolikova A. A. Rakhalina K. K. Rumyantseva A. A. Samkov I. N. Tyurin |
| author_facet | М. А. Sayfullin L. N. Mazankova A. Yu. Rtischev E. N. Abramova N. A. Antypyat N. N. Zvereva O. A. Ivanova M. A. Kolikova A. A. Rakhalina K. K. Rumyantseva A. A. Samkov I. N. Tyurin |
| author_sort | М. А. Sayfullin |
| collection | DOAJ |
| description | In the spring 2022, the number of cases of severe acute hepatitis of unknown etiology was unusual increased in Europe. As an immediate response, the World health organization recommended active efforts to identify such cases at the international level. For monitoring of acute hepatitis in Moscow, patients with suspected liver disease were sent to Infectious Diseases Clinical Hospital No. 1. The goal: study of the structure of diseases occurring with liver damage in children hospitalized in 2022. Materials and methods: analysis of medical records of children hospitalized with a diagnosis of hepatitis from May 1 to December 31, 2022. Еpidemiological data (age, gender, parenteral manipulations, contacts with patients, travel abroad), clinical (fever, jaundice, etc.), laboratory parameters were assessed. Results: A total of 164 completed cases of hepatitis in children aged 5 months to 17 years were analyzed. 36 children met the criteria for probable severe acute hepatitis of unknown etiology. Age median was 7 years [2.25;11]. Girls made up more than half (21 (58.3%). Non-infectious genesis was established in 15 (41.6%). The infectious disease was verified in 11 (30.5%), of which adenoviral infection was detected in 2 children. In 9 (25%) children the etiology of hepatitis was not established. Conclusion. Various infectious and non-infectious diseases among hospitalized children lead to a significant increase in liver transaminases. Most acute hepatitis with unspecified etiology proceeded as an acute infectious disease and ended in recovery. The role of adenoviruses in the development of severe hepatitis in children was not confirmed in our study. |
| format | Article |
| id | doaj-art-13b5162f795740aa9f14fcd59caebc42 |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-13b5162f795740aa9f14fcd59caebc422025-08-20T03:16:17ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072024-11-01234404510.22627/2072-8107-2024-23-4-40-45689Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022М. А. Sayfullin0L. N. Mazankova1A. Yu. Rtischev2E. N. Abramova3N. A. Antypyat4N. N. Zvereva5O. A. Ivanova6M. A. Kolikova7A. A. Rakhalina8K. K. Rumyantseva9A. A. Samkov10I. N. Tyurin11Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationRussian Medical Academy of Postgraduate Education Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of the Russian FederationInfectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthInfectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthPirogov Russian National Research Medical University, Ministry of Health of the Russian FederationInfectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthPirogov Russian National Research Medical University, Ministry of Health of the Russian FederationMorozov Children’s Clinical Hospital of the Moscow Healthcare DepartmentInfectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthInfectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation ; Infectious Diseases Clinical Hospital No. 1 of the Moscow Department of HealthIn the spring 2022, the number of cases of severe acute hepatitis of unknown etiology was unusual increased in Europe. As an immediate response, the World health organization recommended active efforts to identify such cases at the international level. For monitoring of acute hepatitis in Moscow, patients with suspected liver disease were sent to Infectious Diseases Clinical Hospital No. 1. The goal: study of the structure of diseases occurring with liver damage in children hospitalized in 2022. Materials and methods: analysis of medical records of children hospitalized with a diagnosis of hepatitis from May 1 to December 31, 2022. Еpidemiological data (age, gender, parenteral manipulations, contacts with patients, travel abroad), clinical (fever, jaundice, etc.), laboratory parameters were assessed. Results: A total of 164 completed cases of hepatitis in children aged 5 months to 17 years were analyzed. 36 children met the criteria for probable severe acute hepatitis of unknown etiology. Age median was 7 years [2.25;11]. Girls made up more than half (21 (58.3%). Non-infectious genesis was established in 15 (41.6%). The infectious disease was verified in 11 (30.5%), of which adenoviral infection was detected in 2 children. In 9 (25%) children the etiology of hepatitis was not established. Conclusion. Various infectious and non-infectious diseases among hospitalized children lead to a significant increase in liver transaminases. Most acute hepatitis with unspecified etiology proceeded as an acute infectious disease and ended in recovery. The role of adenoviruses in the development of severe hepatitis in children was not confirmed in our study.https://detinf.elpub.ru/jour/article/view/994childrenhepatitisviralunknown etiologyalanine aminotransferaseaspartate transaminaseadenoviruscovid-19infectionstoxic hepatitis |
| spellingShingle | М. А. Sayfullin L. N. Mazankova A. Yu. Rtischev E. N. Abramova N. A. Antypyat N. N. Zvereva O. A. Ivanova M. A. Kolikova A. A. Rakhalina K. K. Rumyantseva A. A. Samkov I. N. Tyurin Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 Детские инфекции (Москва) children hepatitis viral unknown etiology alanine aminotransferase aspartate transaminase adenovirus covid-19 infections toxic hepatitis |
| title | Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 |
| title_full | Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 |
| title_fullStr | Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 |
| title_full_unstemmed | Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 |
| title_short | Results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in Мoscow in 2022 |
| title_sort | results of monitoring probable cases of acute severe hepatitis of unknown etiology in children in мoscow in 2022 |
| topic | children hepatitis viral unknown etiology alanine aminotransferase aspartate transaminase adenovirus covid-19 infections toxic hepatitis |
| url | https://detinf.elpub.ru/jour/article/view/994 |
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