Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases
Curcumin reveals potential in treating an array of cardiovascular diseases (CVDs), including lowering cholesterol and preventing the advancement of atherosclerosis. Heart failure, aortic aneurysm, cardiac ischemia, stroke, myocardial infarction, diabetic cardiovascular issues, drug-induced cardiotox...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400478X |
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| author | Qing Sun Mei Lv Yuhui Li |
| author_facet | Qing Sun Mei Lv Yuhui Li |
| author_sort | Qing Sun |
| collection | DOAJ |
| description | Curcumin reveals potential in treating an array of cardiovascular diseases (CVDs), including lowering cholesterol and preventing the advancement of atherosclerosis. Heart failure, aortic aneurysm, cardiac ischemia, stroke, myocardial infarction, diabetic cardiovascular issues, drug-induced cardiotoxicity, cardiac hypertrophy, and reperfusion injury are among the disorders, it offers cardioprotective benefits. Nonetheless, curcumin’s clinical application is constrained by its limited bioavailability, which reduces its effectiveness when administered orally. To overcome this limitation, nanoformulations of curcumin and its derivatives have been developed to enhance their delivery and absorption. This review provides details about mechanisms and targets of curcumin in CVDs and also critically analyzes current literature on nanotechnology-based delivery systems for curcumin in the treatment of CVDs, emphasizing formulation properties, experimental evidence, and bioactivity, as well as the challenges and opportunities involved in advancing these innovative therapeutic approaches. |
| format | Article |
| id | doaj-art-13b0d1a56d194b10abf1cdf0fe9e09b5 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-13b0d1a56d194b10abf1cdf0fe9e09b52024-11-16T05:10:35ZengElsevierJournal of Functional Foods1756-46462024-11-01122106476Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseasesQing Sun0Mei Lv1Yuhui Li2Department of Cardiology, Yantaishan Hospital, Yantai, Shandong 264000, ChinaGeneral Medicine Department, Yantaishan Hospital, Yantai, Shandong 264000, ChinaDepartment of Cardiology, Yantaishan Hospital, Yantai, Shandong 264000, China; Corresponding author.Curcumin reveals potential in treating an array of cardiovascular diseases (CVDs), including lowering cholesterol and preventing the advancement of atherosclerosis. Heart failure, aortic aneurysm, cardiac ischemia, stroke, myocardial infarction, diabetic cardiovascular issues, drug-induced cardiotoxicity, cardiac hypertrophy, and reperfusion injury are among the disorders, it offers cardioprotective benefits. Nonetheless, curcumin’s clinical application is constrained by its limited bioavailability, which reduces its effectiveness when administered orally. To overcome this limitation, nanoformulations of curcumin and its derivatives have been developed to enhance their delivery and absorption. This review provides details about mechanisms and targets of curcumin in CVDs and also critically analyzes current literature on nanotechnology-based delivery systems for curcumin in the treatment of CVDs, emphasizing formulation properties, experimental evidence, and bioactivity, as well as the challenges and opportunities involved in advancing these innovative therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S175646462400478XNanotechnologyDrug delivery systemCardiovascular diseasesCurcuminCurcumin derivativesBioavailability |
| spellingShingle | Qing Sun Mei Lv Yuhui Li Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases Journal of Functional Foods Nanotechnology Drug delivery system Cardiovascular diseases Curcumin Curcumin derivatives Bioavailability |
| title | Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| title_full | Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| title_fullStr | Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| title_full_unstemmed | Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| title_short | Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| title_sort | nanotechnology based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases |
| topic | Nanotechnology Drug delivery system Cardiovascular diseases Curcumin Curcumin derivatives Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S175646462400478X |
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