R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania

R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania

Abstract Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania, a human protozoan parasite, displays an unconventional DNA replication program in which the timing of DNA replication comple...

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Bibliographic Details
Main Authors: Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56785-y
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