Recent advances on the role of G0S2
Abstract G0S2, formally known as G0/G1 switch gene 2, functions as an inhibitor of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis that hydrolyzes triglycerides (TG) to diacylglycerol and fatty acid (FA). G0S2 can directly interact with ATGL, suppressing its hydrolase activity. Recentl...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03198-4 |
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| author | Xin Hua Zhao Liqin Ruan |
| author_facet | Xin Hua Zhao Liqin Ruan |
| author_sort | Xin Hua Zhao |
| collection | DOAJ |
| description | Abstract G0S2, formally known as G0/G1 switch gene 2, functions as an inhibitor of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis that hydrolyzes triglycerides (TG) to diacylglycerol and fatty acid (FA). G0S2 can directly interact with ATGL, suppressing its hydrolase activity. Recently, G0S2 has been implicated in immune system abnormalities, chronic inflammation, and tumorigenesis. However, the underlying mechanisms and roles of G0S2 in immune system disorders and cancer remain incompletely understood. In this review, we provide an overview of the current knowledge on G0S2, highlighting its regulation at different levels and unveiling its potential as a diagnostic and prognostic marker in immune-related diseases and cancer. The discussion covers the roles of G0S2 in lipolysis, lipid synthesis, inflammation, and various cancers. |
| format | Article |
| id | doaj-art-13a7659c16894e3e98ceb2cfcda4d729 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-13a7659c16894e3e98ceb2cfcda4d7292025-08-20T03:05:09ZengSpringerDiscover Oncology2730-60112025-07-0116112610.1007/s12672-025-03198-4Recent advances on the role of G0S2Xin Hua Zhao0Liqin Ruan1Department of hepatobiliary surgery Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People’s HospitalDepartment of hepatobiliary surgery Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People’s HospitalAbstract G0S2, formally known as G0/G1 switch gene 2, functions as an inhibitor of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis that hydrolyzes triglycerides (TG) to diacylglycerol and fatty acid (FA). G0S2 can directly interact with ATGL, suppressing its hydrolase activity. Recently, G0S2 has been implicated in immune system abnormalities, chronic inflammation, and tumorigenesis. However, the underlying mechanisms and roles of G0S2 in immune system disorders and cancer remain incompletely understood. In this review, we provide an overview of the current knowledge on G0S2, highlighting its regulation at different levels and unveiling its potential as a diagnostic and prognostic marker in immune-related diseases and cancer. The discussion covers the roles of G0S2 in lipolysis, lipid synthesis, inflammation, and various cancers.https://doi.org/10.1007/s12672-025-03198-4G0/G1 switch gene 2Adipose triglyceride lipaseLipolysisInflammationCancer |
| spellingShingle | Xin Hua Zhao Liqin Ruan Recent advances on the role of G0S2 Discover Oncology G0/G1 switch gene 2 Adipose triglyceride lipase Lipolysis Inflammation Cancer |
| title | Recent advances on the role of G0S2 |
| title_full | Recent advances on the role of G0S2 |
| title_fullStr | Recent advances on the role of G0S2 |
| title_full_unstemmed | Recent advances on the role of G0S2 |
| title_short | Recent advances on the role of G0S2 |
| title_sort | recent advances on the role of g0s2 |
| topic | G0/G1 switch gene 2 Adipose triglyceride lipase Lipolysis Inflammation Cancer |
| url | https://doi.org/10.1007/s12672-025-03198-4 |
| work_keys_str_mv | AT xinhuazhao recentadvancesontheroleofg0s2 AT liqinruan recentadvancesontheroleofg0s2 |