Pharyngeal airway dimensions and adipose distribution in the minipig
Objective: To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model. Materials and methods: Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824001805 |
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| author | Doris H. Rosero Salazar Riana Grewal Anuj Vimawala Daniel F. Leotta Swati R. Levendovszky Zi-Jun Liu |
| author_facet | Doris H. Rosero Salazar Riana Grewal Anuj Vimawala Daniel F. Leotta Swati R. Levendovszky Zi-Jun Liu |
| author_sort | Doris H. Rosero Salazar |
| collection | DOAJ |
| description | Objective: To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model. Materials and methods: Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence. Respiratory airflow velocity, pressure, and volume were also recorded. The sizes of velopharyngeal and oropharyngeal airway, and retroglossal areas were measured coronally during inspiration and expiration. The airway volumes from the nasal cavity to the retroglossal space were segmented, reconstructed, and evaluated in sagittal views. The adipose distribution in the tongue base, soft palate, pharyngeal wall, tongue body, and masseter muscle (reference) were segmented and measured in sagittal and coronal planes. Results: The velopharyngeal and oropharyngeal areas were larger in inspiration than in expiration. These areas were also larger than that in the retroglossal space (p < 0.05). The nasal cavity showed a larger volume than that of the pharyngeal regions (p < 0.05). The adipose distribution was larger in the posterior region of the tongue base and anterior soft palate, both larger than the masseter muscle (p < 0.05). Conclusion: The larger oropharyngeal dimensions and increased adipose distribution in the tongue base contribute to the functional morphology of the pharyngeal airway in the healthy minipig. These data provide the baseline for further analysis in enlarged and reduced tongue base minipig models. |
| format | Article |
| id | doaj-art-13a6acabbf064dca9a97138fecbdb9bf |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-13a6acabbf064dca9a97138fecbdb9bf2025-02-09T05:00:11ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-01-011517783Pharyngeal airway dimensions and adipose distribution in the minipigDoris H. Rosero Salazar0Riana Grewal1Anuj Vimawala2Daniel F. Leotta3Swati R. Levendovszky4Zi-Jun Liu5Department of Orthodontics, University of Washington, Seattle, USADepartment of Orthodontics, University of Washington, Seattle, USACenter for Lung Biology, University of Washington, Seattle, USACenter for Industrial and Medical Ultrasound/Applied Physics Laboratory, University of Washington, Seattle, USADepartment of Radiology, University of Washington, Seattle, USADepartment of Orthodontics, University of Washington, Seattle, USA; Corresponding author. Department of Orthodontics, University of Washington, Box 357446, Seattle, WA, 98105, USA.Objective: To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model. Materials and methods: Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence. Respiratory airflow velocity, pressure, and volume were also recorded. The sizes of velopharyngeal and oropharyngeal airway, and retroglossal areas were measured coronally during inspiration and expiration. The airway volumes from the nasal cavity to the retroglossal space were segmented, reconstructed, and evaluated in sagittal views. The adipose distribution in the tongue base, soft palate, pharyngeal wall, tongue body, and masseter muscle (reference) were segmented and measured in sagittal and coronal planes. Results: The velopharyngeal and oropharyngeal areas were larger in inspiration than in expiration. These areas were also larger than that in the retroglossal space (p < 0.05). The nasal cavity showed a larger volume than that of the pharyngeal regions (p < 0.05). The adipose distribution was larger in the posterior region of the tongue base and anterior soft palate, both larger than the masseter muscle (p < 0.05). Conclusion: The larger oropharyngeal dimensions and increased adipose distribution in the tongue base contribute to the functional morphology of the pharyngeal airway in the healthy minipig. These data provide the baseline for further analysis in enlarged and reduced tongue base minipig models.http://www.sciencedirect.com/science/article/pii/S2212426824001805Tongue baseSoft palatePharyngeal airwayMagnetic resonance imagingMinipig |
| spellingShingle | Doris H. Rosero Salazar Riana Grewal Anuj Vimawala Daniel F. Leotta Swati R. Levendovszky Zi-Jun Liu Pharyngeal airway dimensions and adipose distribution in the minipig Journal of Oral Biology and Craniofacial Research Tongue base Soft palate Pharyngeal airway Magnetic resonance imaging Minipig |
| title | Pharyngeal airway dimensions and adipose distribution in the minipig |
| title_full | Pharyngeal airway dimensions and adipose distribution in the minipig |
| title_fullStr | Pharyngeal airway dimensions and adipose distribution in the minipig |
| title_full_unstemmed | Pharyngeal airway dimensions and adipose distribution in the minipig |
| title_short | Pharyngeal airway dimensions and adipose distribution in the minipig |
| title_sort | pharyngeal airway dimensions and adipose distribution in the minipig |
| topic | Tongue base Soft palate Pharyngeal airway Magnetic resonance imaging Minipig |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824001805 |
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