Demographic drivers of gut microbiome diversity
Abstract The gut microbiome plays a central role in orchestrating metabolic, immune, and neurological functions essential for human health. While extensive research has explored the effects of diseases and pathological conditions on gut microbiome composition, the influence of demographic factors re...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-08-01
|
| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-025-01921-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761093514166272 |
|---|---|
| author | Hannaneh Kabir Matilda Holtz Justine Choueiri Mohammad Reza Kaazempur Mofrad |
| author_facet | Hannaneh Kabir Matilda Holtz Justine Choueiri Mohammad Reza Kaazempur Mofrad |
| author_sort | Hannaneh Kabir |
| collection | DOAJ |
| description | Abstract The gut microbiome plays a central role in orchestrating metabolic, immune, and neurological functions essential for human health. While extensive research has explored the effects of diseases and pathological conditions on gut microbiome composition, the influence of demographic factors remains underexplored, limiting our understanding of microbiome variations in disease states. This study addresses this gap by investigating the impact of demographic variables, including age, sex, and geography, on gut microbiome diversity in healthy individuals. Using the American Gut Project’s extensive dataset and the QIIME2 bioinformatics pipeline, we conducted a comprehensive analysis of microbial profiles across diverse demographic groups. Our results revealed significant age-related shifts in microbial richness and composition, and geographic location strongly influenced phylogenetic diversity. In contrast, sex exhibited limited impact on microbial diversity within healthy BMI ranges. These findings highlight the critical role of demographic factors in shaping gut microbiome diversity, providing a foundational framework to better contextualize disease-related microbiome variations and advance personalized healthcare approaches. |
| format | Article |
| id | doaj-art-13a49239dfd74e66ba4fb86ce9388b07 |
| institution | DOAJ |
| issn | 2191-0855 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj-art-13a49239dfd74e66ba4fb86ce9388b072025-08-20T03:06:08ZengSpringerOpenAMB Express2191-08552025-08-0115111710.1186/s13568-025-01921-6Demographic drivers of gut microbiome diversityHannaneh Kabir0Matilda Holtz1Justine Choueiri2Mohammad Reza Kaazempur Mofrad3Molecular Cell Biomechanics Lab, Departments of Bioengineering and Mechanical Engineering, University of California BerkeleyMolecular Cell Biomechanics Lab, Departments of Bioengineering and Mechanical Engineering, University of California BerkeleyMolecular Cell Biomechanics Lab, Departments of Bioengineering and Mechanical Engineering, University of California BerkeleyMolecular Cell Biomechanics Lab, Departments of Bioengineering and Mechanical Engineering, University of California BerkeleyAbstract The gut microbiome plays a central role in orchestrating metabolic, immune, and neurological functions essential for human health. While extensive research has explored the effects of diseases and pathological conditions on gut microbiome composition, the influence of demographic factors remains underexplored, limiting our understanding of microbiome variations in disease states. This study addresses this gap by investigating the impact of demographic variables, including age, sex, and geography, on gut microbiome diversity in healthy individuals. Using the American Gut Project’s extensive dataset and the QIIME2 bioinformatics pipeline, we conducted a comprehensive analysis of microbial profiles across diverse demographic groups. Our results revealed significant age-related shifts in microbial richness and composition, and geographic location strongly influenced phylogenetic diversity. In contrast, sex exhibited limited impact on microbial diversity within healthy BMI ranges. These findings highlight the critical role of demographic factors in shaping gut microbiome diversity, providing a foundational framework to better contextualize disease-related microbiome variations and advance personalized healthcare approaches.https://doi.org/10.1186/s13568-025-01921-6Gut microbiome diversityDemographic factorsAlpha diversityBeta diversityQIIME2 analysisMicrobial community composition |
| spellingShingle | Hannaneh Kabir Matilda Holtz Justine Choueiri Mohammad Reza Kaazempur Mofrad Demographic drivers of gut microbiome diversity AMB Express Gut microbiome diversity Demographic factors Alpha diversity Beta diversity QIIME2 analysis Microbial community composition |
| title | Demographic drivers of gut microbiome diversity |
| title_full | Demographic drivers of gut microbiome diversity |
| title_fullStr | Demographic drivers of gut microbiome diversity |
| title_full_unstemmed | Demographic drivers of gut microbiome diversity |
| title_short | Demographic drivers of gut microbiome diversity |
| title_sort | demographic drivers of gut microbiome diversity |
| topic | Gut microbiome diversity Demographic factors Alpha diversity Beta diversity QIIME2 analysis Microbial community composition |
| url | https://doi.org/10.1186/s13568-025-01921-6 |
| work_keys_str_mv | AT hannanehkabir demographicdriversofgutmicrobiomediversity AT matildaholtz demographicdriversofgutmicrobiomediversity AT justinechoueiri demographicdriversofgutmicrobiomediversity AT mohammadrezakaazempurmofrad demographicdriversofgutmicrobiomediversity |