Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats
This study aimed to assess the sedative and physiological effects of three alpha2-agonists in Barbari goats. Eighteen healthy goats (20.3 ± 0.8 kg, 16 ± 2.2 months) were administered xylazine (100 μg/kg; XYL), detomidine (50 μg/kg; DET), or medetomidine (6 μg/kg; MED). Heart rate, respiratory rate,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Journal of Applied Animal Research |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09712119.2025.2527822 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849320707292397568 |
|---|---|
| author | Zahir Shah Abd Ullah Shabana Naz Taif Shah Abdul Aziz Kasim Sakran Abass Ibrahim A. Alhidary Rifat Ullah Khan Muhammad Israr |
| author_facet | Zahir Shah Abd Ullah Shabana Naz Taif Shah Abdul Aziz Kasim Sakran Abass Ibrahim A. Alhidary Rifat Ullah Khan Muhammad Israr |
| author_sort | Zahir Shah |
| collection | DOAJ |
| description | This study aimed to assess the sedative and physiological effects of three alpha2-agonists in Barbari goats. Eighteen healthy goats (20.3 ± 0.8 kg, 16 ± 2.2 months) were administered xylazine (100 μg/kg; XYL), detomidine (50 μg/kg; DET), or medetomidine (6 μg/kg; MED). Heart rate, respiratory rate, rectal temperature, serum glucose concentration, and sedation duration were recorded. Heart rate significantly decreased within 5 minutes, reaching its lowest at 50, 40, and 25 minutes in the XYL, DET, and MED groups, respectively. Respiratory rate declined within 5 minutes, with the greatest reduction observed at 20 minutes in XYL and DET groups and at 25 minutes in the MED group. Rectal temperature significantly dropped at 15 minutes in XYL and MED groups and at 45 minutes in DET. Serum glucose levels increased at 30 minutes post-administration. The onset of sedation were 29 ± 3.74, 55.66 ± 5.57, and 28.83 ± 5.98 s and the onset of optimal sedation were 5 ± 2.28, 12.16 ± 2.99, and 9.75 ± 2.75 minutes, and the total duration of sedation were 77.59 ± 4.38, 85.38 ± 2.76, and 72.64 ± 4.35 minutes in the XYL, DET, and MED groups, respectively. All three alpha2-agonists can be safely used for pain relief during physical examinations and minor surgical procedures in goats. |
| format | Article |
| id | doaj-art-13a2d3438f1a4592b03f1a2cb8a6930a |
| institution | Kabale University |
| issn | 0971-2119 0974-1844 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj-art-13a2d3438f1a4592b03f1a2cb8a6930a2025-08-20T03:50:00ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442025-12-0153110.1080/09712119.2025.2527822Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goatsZahir Shah0Abd Ullah1Shabana Naz2Taif Shah3Abdul Aziz4Kasim Sakran Abass5Ibrahim A. Alhidary6Rifat Ullah Khan7Muhammad Israr8College of Veterinary Sciences, The University of Agriculture, Peshawar, PakistanCollege of Veterinary Sciences, The University of Agriculture, Peshawar, PakistanDepartment of Zoology, Government College University, Faisalabad, PakistanState Key Laboratory of Conservation and Bio-resources in Yunnan, Yunnan University, Kunming, People’s Republic of ChinaFaculty of Veterinary and Animal Sciences, University of Poonch, Rawalakot, PakistanDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, IraqDepartment of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi ArabiaCollege of Veterinary Sciences, The University of Agriculture, Peshawar, PakistanCollege of Veterinary Sciences, The University of Agriculture, Peshawar, PakistanThis study aimed to assess the sedative and physiological effects of three alpha2-agonists in Barbari goats. Eighteen healthy goats (20.3 ± 0.8 kg, 16 ± 2.2 months) were administered xylazine (100 μg/kg; XYL), detomidine (50 μg/kg; DET), or medetomidine (6 μg/kg; MED). Heart rate, respiratory rate, rectal temperature, serum glucose concentration, and sedation duration were recorded. Heart rate significantly decreased within 5 minutes, reaching its lowest at 50, 40, and 25 minutes in the XYL, DET, and MED groups, respectively. Respiratory rate declined within 5 minutes, with the greatest reduction observed at 20 minutes in XYL and DET groups and at 25 minutes in the MED group. Rectal temperature significantly dropped at 15 minutes in XYL and MED groups and at 45 minutes in DET. Serum glucose levels increased at 30 minutes post-administration. The onset of sedation were 29 ± 3.74, 55.66 ± 5.57, and 28.83 ± 5.98 s and the onset of optimal sedation were 5 ± 2.28, 12.16 ± 2.99, and 9.75 ± 2.75 minutes, and the total duration of sedation were 77.59 ± 4.38, 85.38 ± 2.76, and 72.64 ± 4.35 minutes in the XYL, DET, and MED groups, respectively. All three alpha2-agonists can be safely used for pain relief during physical examinations and minor surgical procedures in goats.https://www.tandfonline.com/doi/10.1080/09712119.2025.2527822Alpha2-agonistBarbari goatdetomidinedrugphysiological parametersxylazine |
| spellingShingle | Zahir Shah Abd Ullah Shabana Naz Taif Shah Abdul Aziz Kasim Sakran Abass Ibrahim A. Alhidary Rifat Ullah Khan Muhammad Israr Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats Journal of Applied Animal Research Alpha2-agonist Barbari goat detomidine drug physiological parameters xylazine |
| title | Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats |
| title_full | Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats |
| title_fullStr | Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats |
| title_full_unstemmed | Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats |
| title_short | Comparative evaluation of the sedative and physiological effects of xylazine, detomidine, and medetomidine in Barbari goats |
| title_sort | comparative evaluation of the sedative and physiological effects of xylazine detomidine and medetomidine in barbari goats |
| topic | Alpha2-agonist Barbari goat detomidine drug physiological parameters xylazine |
| url | https://www.tandfonline.com/doi/10.1080/09712119.2025.2527822 |
| work_keys_str_mv | AT zahirshah comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT abdullah comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT shabananaz comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT taifshah comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT abdulaziz comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT kasimsakranabass comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT ibrahimaalhidary comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT rifatullahkhan comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats AT muhammadisrar comparativeevaluationofthesedativeandphysiologicaleffectsofxylazinedetomidineandmedetomidineinbarbarigoats |