The Role of Macrophages in Tumor Development
Macrophages constitute a large proportion of the immune cell infiltrate, which is present in many tumors. Activation state of macrophages is greatly influenced by their environment, leading to different macrophage subsets with diverse functions. Although previously regarded as potent immune cells th...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2005/719412 |
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| _version_ | 1849304449794703360 |
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| author | Gerben J. van der Bij Steven J. Oosterling Sybren Meijer Robert H. J. Beelen Marjolein van Egmond |
| author_facet | Gerben J. van der Bij Steven J. Oosterling Sybren Meijer Robert H. J. Beelen Marjolein van Egmond |
| author_sort | Gerben J. van der Bij |
| collection | DOAJ |
| description | Macrophages constitute a large proportion of the immune cell infiltrate, which is present in many tumors. Activation state of macrophages is greatly influenced by their environment, leading to different macrophage subsets with diverse functions. Although previously regarded as potent immune cells that are capable of destroying tumor cells, recent literature focuses on the ability of macrophages to promote tumor development due to secretion of mediators, like growth and angiogenic factors. It is now becoming increasingly clear that a complicated synergistic relationship exists between macrophages and malignant cells whereby tumor cells can affect macrophage phenotype, and vice versa. As such, macrophages and their contribution in cancer development are currently subject of debate. |
| format | Article |
| id | doaj-art-139ff8bb38734d25a32495fcf64e0061 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-139ff8bb38734d25a32495fcf64e00612025-08-20T03:55:44ZengWileyCellular Oncology1570-58701875-86062005-01-0127420321310.1155/2005/719412The Role of Macrophages in Tumor DevelopmentGerben J. van der Bij0Steven J. Oosterling1Sybren Meijer2Robert H. J. Beelen3Marjolein van Egmond4Department of Surgical Oncology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Surgical Oncology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Surgical Oncology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Surgical Oncology, VU University Medical Center, Amsterdam, The NetherlandsMacrophages constitute a large proportion of the immune cell infiltrate, which is present in many tumors. Activation state of macrophages is greatly influenced by their environment, leading to different macrophage subsets with diverse functions. Although previously regarded as potent immune cells that are capable of destroying tumor cells, recent literature focuses on the ability of macrophages to promote tumor development due to secretion of mediators, like growth and angiogenic factors. It is now becoming increasingly clear that a complicated synergistic relationship exists between macrophages and malignant cells whereby tumor cells can affect macrophage phenotype, and vice versa. As such, macrophages and their contribution in cancer development are currently subject of debate.http://dx.doi.org/10.1155/2005/719412 |
| spellingShingle | Gerben J. van der Bij Steven J. Oosterling Sybren Meijer Robert H. J. Beelen Marjolein van Egmond The Role of Macrophages in Tumor Development Cellular Oncology |
| title | The Role of Macrophages in Tumor Development |
| title_full | The Role of Macrophages in Tumor Development |
| title_fullStr | The Role of Macrophages in Tumor Development |
| title_full_unstemmed | The Role of Macrophages in Tumor Development |
| title_short | The Role of Macrophages in Tumor Development |
| title_sort | role of macrophages in tumor development |
| url | http://dx.doi.org/10.1155/2005/719412 |
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