AMTAC-19, a Spiro-Acridine Compound, Induces In Vitro Antitumor Effect via the ROS-ERK/JNK Signaling Pathway

AMTAC-19, a Spiro-Acridine Compound, Induces In Vitro Antitumor Effect via the ROS-ERK/JNK Signaling Pathway

Colorectal cancer remains a significant cause of mortality worldwide. A spiro-acridine derivative, (<i>E</i>)-1′-((4-bromobenzylidene)amino)-5′-oxo-1′,5′-dihydro-10<i>H</i>-spiro[acridine-9,2′-pyrrole]-4′-carbonitrile (AMTAC-19), showed significant cytotoxicity in HCT-116 col...

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Bibliographic Details
Main Authors: Valgrícia Matias de Sousa, Sâmia Sousa Duarte, Rafael Carlos Ferreira, Natália Ferreira de Sousa, Marcus Tullius Scotti, Luciana Scotti, Marcelo Sobral da Silva, Josean Fechine Tavares, Ricardo Olímpio de Moura, Juan Carlos Ramos Gonçalves, Marianna Vieira Sobral
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
colorectal carcinoma
oxidative stress
MAPKs
Online Access:https://www.mdpi.com/1420-3049/29/22/5344
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