Development and Validation of a Highly Sensitive LC–MS/MS Method for the Precise Quantification of Sitagliptin in Human Plasma and Its Application to Pharmacokinetic Study

Development and Validation of a Highly Sensitive LC–MS/MS Method for the Precise Quantification of Sitagliptin in Human Plasma and Its Application to Pharmacokinetic Study

Sitagliptin is an orally bioavailable selective DPP4 inhibitor that reduces blood glucose levels without significant increases in hypoglycemia. The aim of this study was to design and validate an innovative, rapid, and highly sensitive LC–MS/MS assay for the precise measurement of sitagliptin concen...

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Bibliographic Details
Main Authors: Yuna Song, Wang-Seob Shim, Eunseo Song, Yebeen Park, Bo-Hyung Kim, Sangmin Lee, Eun Kyoung Chung, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
sitagliptin
human plasma
bioanalytical method validation
pharmacokinetics
dipeptidyl peptidase-4 inhibitor
LC-MS/MS
Online Access:https://www.mdpi.com/1420-3049/30/14/2995
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