Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma

Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma

Background: Multiple myeloma (MM) patients are at high risk of severe infections including COVID-19 due to an immune dysregulation affecting both innate and adaptive immune responses. However, our understanding of the immune responses to infection and vaccination in MM patients is limited. To gain m...

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Main Authors: Khalid Shoumariyeh, Benedikt Csernalabics, Elahe Salimi Alizei, Matthias Reinscheid, Sebastian Giese, Kevin Ciminski, Georg Kochs, Martin Schwemmle, Julia Lang-Meli, Michelle Maas, Natascha Roehlen, Vivien Karl, Anne Graeser, Oezlem Sogukpinar, Ivana von Metzler, Denise Grathwohl, Leo Rasche, Holger Hebart, Miriam Kull, Florian Emmerich, Cornelius Florian Waller, Justus Duyster, Monika Engelhardt, Tanja Nicole Hartmann, Bertram Bengsch, Tobias Boettler, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Hendrik Luxenburger
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
multiple myeloma
immunosuppression
COVID-19
SARS-CoV-2
mRNA vaccination
infection
Online Access:https://www.mdpi.com/2076-393X/12/11/1249
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