Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder experienced by women of reproductive age and is marked by insulin resistance (IR) and menstrual cycle abnormalities. In this study, we set out to assess how the level of menstrual abnormalities relates to the degree of IR in women...
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Springer
2023-06-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423000804 |
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| author | Khulood Hussein Mohammed Karami |
| author_facet | Khulood Hussein Mohammed Karami |
| author_sort | Khulood Hussein |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder experienced by women of reproductive age and is marked by insulin resistance (IR) and menstrual cycle abnormalities. In this study, we set out to assess how the level of menstrual abnormalities relates to the degree of IR in women with PCOS. Methods: The participants in this study were 93 women diagnosed with PCOS and 100 controls with regular vaginal bleeding. Data was collected through blood samples, physical examinations, and medical histories. The primary outcome measures were body mass index (BMI), fasting glucose, fasting insulin, homeostatic model assessment for IR (HOMA-IR), and hormonal parameters. Results: Values for BMI and HOMA-IR were higher in PCOS cases than in controls [(28.6 ± 1.9 vs. 23.7 ± 2.3) and (2.29 ± 2.87 vs. 1.48 ± 1.02), respectively]. Oligomenorrhea was documented in 79.4% of women with PCOS, with the others experienced vaginal bleeding intervals under 45 days. The greater the menstrual irregularity, the higher the levels of luteinizing hormone/follicle-stimulating hormone and testosterone. Among the PCOS group, those with vaginal bleeding intervals of above 90 days had a higher HOMA-IR values (2.46 ± 2.77), after adjustments for age and BMI, than the participants who went<45 days between periods (2.01 ± 2.14) and those whose interval was 45–90 days (2.09 ± 2.43). Conclusions: Most of the participants with PCOS had obvious oligomenorrhea of at least 6 weeks between episodes of vaginal bleeding and had significantly higher insulin resistance than did the controls. This suggests that insulin resistance in PCOS cases may be predicted by the presence of clinically overt menstrual dysfunction. |
| format | Article |
| id | doaj-art-139408d36fba4e6da9d6445e89ebbb88 |
| institution | Kabale University |
| issn | 1319-0164 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj-art-139408d36fba4e6da9d6445e89ebbb882025-08-20T03:55:44ZengSpringerSaudi Pharmaceutical Journal1319-01642023-06-013161104110810.1016/j.jsps.2023.03.021Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndromeKhulood Hussein0Mohammed Karami1Corresponding author.; Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaBackground: Polycystic ovary syndrome (PCOS) is an endocrine disorder experienced by women of reproductive age and is marked by insulin resistance (IR) and menstrual cycle abnormalities. In this study, we set out to assess how the level of menstrual abnormalities relates to the degree of IR in women with PCOS. Methods: The participants in this study were 93 women diagnosed with PCOS and 100 controls with regular vaginal bleeding. Data was collected through blood samples, physical examinations, and medical histories. The primary outcome measures were body mass index (BMI), fasting glucose, fasting insulin, homeostatic model assessment for IR (HOMA-IR), and hormonal parameters. Results: Values for BMI and HOMA-IR were higher in PCOS cases than in controls [(28.6 ± 1.9 vs. 23.7 ± 2.3) and (2.29 ± 2.87 vs. 1.48 ± 1.02), respectively]. Oligomenorrhea was documented in 79.4% of women with PCOS, with the others experienced vaginal bleeding intervals under 45 days. The greater the menstrual irregularity, the higher the levels of luteinizing hormone/follicle-stimulating hormone and testosterone. Among the PCOS group, those with vaginal bleeding intervals of above 90 days had a higher HOMA-IR values (2.46 ± 2.77), after adjustments for age and BMI, than the participants who went<45 days between periods (2.01 ± 2.14) and those whose interval was 45–90 days (2.09 ± 2.43). Conclusions: Most of the participants with PCOS had obvious oligomenorrhea of at least 6 weeks between episodes of vaginal bleeding and had significantly higher insulin resistance than did the controls. This suggests that insulin resistance in PCOS cases may be predicted by the presence of clinically overt menstrual dysfunction.http://www.sciencedirect.com/science/article/pii/S1319016423000804Menstrual dysfunctionPolycystic ovary syndromeInsulin resistanceGlucose metabolismHyperandrogenism |
| spellingShingle | Khulood Hussein Mohammed Karami Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome Saudi Pharmaceutical Journal Menstrual dysfunction Polycystic ovary syndrome Insulin resistance Glucose metabolism Hyperandrogenism |
| title | Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome |
| title_full | Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome |
| title_fullStr | Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome |
| title_full_unstemmed | Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome |
| title_short | Association between insulin resistance and abnormal menstrual cycle in Saudi females with polycystic ovary syndrome |
| title_sort | association between insulin resistance and abnormal menstrual cycle in saudi females with polycystic ovary syndrome |
| topic | Menstrual dysfunction Polycystic ovary syndrome Insulin resistance Glucose metabolism Hyperandrogenism |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423000804 |
| work_keys_str_mv | AT khuloodhussein associationbetweeninsulinresistanceandabnormalmenstrualcycleinsaudifemaleswithpolycysticovarysyndrome AT mohammedkarami associationbetweeninsulinresistanceandabnormalmenstrualcycleinsaudifemaleswithpolycysticovarysyndrome |