Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients
Background. The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6666086 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550255411855360 |
|---|---|
| author | Shayesteh Khalili Tahereh Sabaghian Meghdad Sedaghat Zahra Soroureddin Elham Askari Neda Khalili |
| author_facet | Shayesteh Khalili Tahereh Sabaghian Meghdad Sedaghat Zahra Soroureddin Elham Askari Neda Khalili |
| author_sort | Shayesteh Khalili |
| collection | DOAJ |
| description | Background. The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patients with diabetes. Material and Methods. This retrospective cohort study included 254 patients (127 with diabetes and 127 without diabetes) who were admitted for COVID-19 to a tertiary hospital in Tehran, Iran, between February and May 2020. Clinical characteristics and outcomes, radiological findings, and laboratory data, including data on AKI, hematuria, and proteinuria were recorded and analyzed. Results. Of 254 patients, 142 (55.9%) were male and the mean (± SD) age was 65.7 years (±12.5). In total, 58 patients (22.8%) developed AKI during hospitalization, of whom 36 patients had diabetes (p=0.04); most patients (74.1%) had stage 1 or 2 AKI. Also, 8 patients (13.8%) required renal replacement therapy (RRT) after developing AKI. Regardless of diabetes status, patients who developed AKI had significantly higher mortality rates compared with patients who did not develop AKI (p=0.02). Hematuria and proteinuria were observed in 38.1% and 55% of patients, respectively. Multivariate analysis showed that invasive mechanical ventilation, proteinuria, HBA1c level, history of cardiovascular disease, and use of statins were independent risk factors for AKI development in patients with diabetes. Conclusion. Results of this study showed that AKI develops in a considerable percentage of patients with COVID-19, especially in those with diabetes, and is significantly associated with mortality. |
| format | Article |
| id | doaj-art-1393601c5cf54180bf8523f3dd328ecb |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1393601c5cf54180bf8523f3dd328ecb2025-02-03T06:07:16ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/66660866666086Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic PatientsShayesteh Khalili0Tahereh Sabaghian1Meghdad Sedaghat2Zahra Soroureddin3Elham Askari4Neda Khalili5Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranBackground. The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patients with diabetes. Material and Methods. This retrospective cohort study included 254 patients (127 with diabetes and 127 without diabetes) who were admitted for COVID-19 to a tertiary hospital in Tehran, Iran, between February and May 2020. Clinical characteristics and outcomes, radiological findings, and laboratory data, including data on AKI, hematuria, and proteinuria were recorded and analyzed. Results. Of 254 patients, 142 (55.9%) were male and the mean (± SD) age was 65.7 years (±12.5). In total, 58 patients (22.8%) developed AKI during hospitalization, of whom 36 patients had diabetes (p=0.04); most patients (74.1%) had stage 1 or 2 AKI. Also, 8 patients (13.8%) required renal replacement therapy (RRT) after developing AKI. Regardless of diabetes status, patients who developed AKI had significantly higher mortality rates compared with patients who did not develop AKI (p=0.02). Hematuria and proteinuria were observed in 38.1% and 55% of patients, respectively. Multivariate analysis showed that invasive mechanical ventilation, proteinuria, HBA1c level, history of cardiovascular disease, and use of statins were independent risk factors for AKI development in patients with diabetes. Conclusion. Results of this study showed that AKI develops in a considerable percentage of patients with COVID-19, especially in those with diabetes, and is significantly associated with mortality.http://dx.doi.org/10.1155/2021/6666086 |
| spellingShingle | Shayesteh Khalili Tahereh Sabaghian Meghdad Sedaghat Zahra Soroureddin Elham Askari Neda Khalili Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients Journal of Diabetes Research |
| title | Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients |
| title_full | Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients |
| title_fullStr | Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients |
| title_full_unstemmed | Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients |
| title_short | Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients |
| title_sort | prevalence risk factors and outcomes associated with acute kidney injury in patients hospitalized for covid 19 a comparative study between diabetic and nondiabetic patients |
| url | http://dx.doi.org/10.1155/2021/6666086 |
| work_keys_str_mv | AT shayestehkhalili prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients AT taherehsabaghian prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients AT meghdadsedaghat prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients AT zahrasoroureddin prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients AT elhamaskari prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients AT nedakhalili prevalenceriskfactorsandoutcomesassociatedwithacutekidneyinjuryinpatientshospitalizedforcovid19acomparativestudybetweendiabeticandnondiabeticpatients |