Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in <i>Eimeria tenella</i>: Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations

Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in <i>Eimeria tenella</i>: Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations

Avian coccidiosis, caused by protozoan parasites of the genus <i>Eimeria</i>, poses a major threat to the poultry industry worldwide, leading to severe economic losses through reduced growth rates, poor feed efficiency, and increased mortality. Although the conventional management of thi...

Full description

Saved in:
Bibliographic Details
Main Authors: Haiming Cai, Shenquan Liao, Juan Li, Minna Lv, Xuhui Lin, Yongle Song, Xiangjie Chen, Yibin Zhu, Jianfei Zhang, Nanshan Qi, Mingfei Sun
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
avian coccidiosis
prolyl-tRNA synthetase
<i>Eimeria tenella</i>
docking protocol
molecular dynamics simulations
ADMET
Online Access:https://www.mdpi.com/1420-3049/30/4/790
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Avian coccidiosis, caused by protozoan parasites of the genus <i>Eimeria</i>, poses a major threat to the poultry industry worldwide, leading to severe economic losses through reduced growth rates, poor feed efficiency, and increased mortality. Although the conventional management of this disease has relied on anticoccidial drugs, the overwhelming use of these agents has led to the rapid emergence and spread of drug-resistant <i>Eimeria</i> isolates, highlighting the urgent need for novel therapeutic approaches. This study employed computational approaches to identify novel inhibitors targeting <i>Eimeria tenella</i> prolyl-tRNA synthetase (EtPRS). Based on the virtual screening of a library of 3045 natural compounds, 42 high-confidence inhibitors were identified. Three compounds, including Chelidonine, Bicuculline, and Guggulsterone, demonstrated strong and selective binding to EtPRS through stable interactions within the active site. ADMET predictions revealed favorable safety profiles, while molecular dynamic simulations confirmed binding stability. Overall, this research established a solid framework for the development of effective anticoccidial agents targeting PRS, contributing to the advancement of therapeutic strategies for combating parasitic infections in the poultry industry.
ISSN:1420-3049

Similar Items